Cancer Program

O-mannosylation and protein maturation checkpoints represent therapeutic opportunities in BRAF fusion protein oncogenesis.

Borgenvik A, Misek SA, Christen D, et al. O-mannosylation and protein maturation checkpoints represent therapeutic opportunities in BRAF fusion protein oncogenesis. Cancer discovery. 2026. doi:10.1158/2159-8290.CD-25-1114Google Scholar PubMed DOI

Conserved neuronal-like and secretory programs define the spatial architecture of gastroenteropancreatic neuroendocrine tumors.

Karam J, Hoffman SE, Garza A, et al. Conserved neuronal-like and secretory programs define the spatial architecture of gastroenteropancreatic neuroendocrine tumors. The Journal of clinical investigation. 2026. doi:10.1172/JCI204119Google Scholar PubMed DOI

Proteo-genomics-guided interpretation of somatic mutations in cancer genomes.

Hyeon DY, Zhou Y, Chung WK, Dietlein F. Proteo-genomics-guided interpretation of somatic mutations in cancer genomes. Cancer cell. 2026. doi:10.1016/j.ccell.2026.07.017Google Scholar PubMed DOI

A dependency map enhanced with next-generation 3D cancer models.

Neiswender J V, Maffa S, Brenan L, et al. A dependency map enhanced with next-generation 3D cancer models. Nature. 2026. doi:10.1038/s41586-026-10843-7Google Scholar PubMed DOI

Ultrasensitive circulating tumor DNA analysis improves detection of molecular residual disease in locally advanced esophageal cancer.

Rhoades J, Patel A, Xiong K, et al. Ultrasensitive circulating tumor DNA analysis improves detection of molecular residual disease in locally advanced esophageal cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2026. doi:10.1158/1078-0432.CCR-25-4852Google Scholar PubMed DOI

U2AF1 mutations rescue deleterious exon skipping induced by KRAS mutations.

Walter DM, Cho K, Sivakumar S, et al. U2AF1 mutations rescue deleterious exon skipping induced by KRAS mutations. Nature genetics. 2026. doi:10.1038/s41588-026-02648-1Google Scholar PubMed DOI

Single-nucleus multimodal spatial transcriptomics reveals spatial colocalization of neoantigen-expressing tumor cells and cognate T cells.

Nagler A, Sud A, Ghannam JY, et al. Single-nucleus multimodal spatial transcriptomics reveals spatial colocalization of neoantigen-expressing tumor cells and cognate T cells. Nature biotechnology. 2026. doi:10.1038/s41587-026-03194-1Google Scholar PubMed DOI

Tertiary lymphoid structures harbour stem-like tumour-specific T cells.

Afeyan AB, Nagler A, Tu CR, et al. Tertiary lymphoid structures harbour stem-like tumour-specific T cells. Nature. 2026. doi:10.1038/s41586-026-10808-wGoogle Scholar PubMed DOI

Genomic correlates of clinical CAR-T cell activity.

Leick MB, Sun B, Birocchi F, et al. Genomic correlates of clinical CAR-T cell activity. Science immunology. 2026;11(121):eaef4134. doi:10.1126/sciimmunol.aef4134Google Scholar PubMed DOI

Publisher Correction: Tumor transcriptional state predicts survival in immune-checkpoint-blockade-treated glioblastoma.

Ghannam JY, Bryan J, Weiss J, et al. Publisher Correction: Tumor transcriptional state predicts survival in immune-checkpoint-blockade-treated glioblastoma. Nature cancer. 2026. doi:10.1038/s43018-026-01197-0Google Scholar PubMed DOI