Koblan LW, Arbab M, Shen MW, et al. Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning. Nature biotechnology. 2021;39(11):1414-1425. doi:10.1038/s41587-021-00938-zPubMedGoogle ScholarDOI
Chemical Biology and Therapeutics Science Program
Hanna RE, Hegde M, Fagre C, et al. Massively parallel assessment of human variants with base editor screens. Cell. 2021;184(4):1064-1080.e20. doi:10.1016/j.cell.2021.01.012PubMedGoogle ScholarDOI
Yang K, Lee M, Jones PA, et al. A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells. Sci Adv. 2020;6(47). doi:10.1126/sciadv.abc3207PubMedGoogle ScholarDOI
Del Amo VL, Leger BS, Cox KJ, et al. Small-Molecule Control of Super-Mendelian Inheritance in Gene Drives. Cell Rep. 2020;31(13):107841. doi:10.1016/j.celrep.2020.107841PubMedGoogle ScholarDOI
Modell AE, Siriwardena SU, Choudhary A. A Jumbo Phage Forms a Nucleus-like Compartment to Evade Bacterial Defense Systems. Biochemistry. 2020;59(20):1869-1870. doi:10.1021/acs.biochem.0c00273PubMedGoogle ScholarDOI
Sreekanth V, Zhou Q, Kokkonda P, et al. Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes. ACS central science. 2020;6(12):2228-2237. doi:10.1021/acscentsci.0c00129PubMedGoogle ScholarDOI
Long K, Alphey L, Annas G, et al. Core commitments for field trials of gene drive organisms. Science (New York, N.Y.). 2020;370(6523):1417-1419. doi:10.1126/science.abd1908PubMedGoogle ScholarDOI
Lee M, Maji B, Manna D, et al. Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in β-Cells. Journal of the American Chemical Society. 2020;142(14):6477-6482. doi:10.1021/jacs.0c00099PubMedGoogle ScholarDOI
Siriwardena SU, Godage DNPM, Shoba VM, et al. Phosphorylation-Inducing Chimeric Small Molecules. Journal of the American Chemical Society. 2020;142(33):14052-14057. doi:10.1021/jacs.0c05537PubMedGoogle ScholarDOI
Lim D, Sreekanth V, Cox KJ, et al. Engineering designer beta cells with a CRISPR-Cas9 conjugation platform. Nature communications. 2020;11(1):4043. doi:10.1038/s41467-020-17725-0PubMedGoogle ScholarDOI