Singh S, Tian W, Severance ZC, et al. Proximity-inducing modalities: the past, present, and future. Chemical Society reviews. 2023. doi:10.1039/d2cs00943aGoogle ScholarPubMedDOI
Chemical Biology and Therapeutics Science Program
Everette KA, Newby GA, Levine RM, et al. Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice. Nature biomedical engineering. 2023. doi:10.1038/s41551-023-01026-0Google ScholarPubMedDOI
Ely ZA, Mathey-Andrews N, Naranjo S, et al. A prime editor mouse to model a broad spectrum of somatic mutations in vivo. Nature biotechnology. 2023. doi:10.1038/s41587-023-01783-yGoogle ScholarPubMedDOI
Doman JL, Pandey S, Neugebauer ME, et al. Phage-assisted evolution and protein engineering yield compact, efficient prime editors. Cell. 2023;186(18):3983-4002.e26. doi:10.1016/j.cell.2023.07.039Google ScholarPubMedDOI
Kwok HS, Freedy AM, Siegenfeld AP, et al. Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma. Nature chemical biology. 2023. doi:10.1038/s41589-023-01299-1Google ScholarPubMedDOI
Mayuranathan T, Newby GA, Feng R, et al. Potent and uniform fetal hemoglobin induction via base editing. Nature genetics. 2023. doi:10.1038/s41588-023-01434-7Google ScholarPubMedDOI
Ngan KCH, Hoenig SM, Kwok HS, et al. Activity-based CRISPR scanning uncovers allostery in DNA methylation maintenance machinery. eLife. 2023;12. doi:10.7554/eLife.80640Google ScholarPubMedDOI
Pergu R, Shoba VM, Chaudhary SK, et al. Development and Applications of Chimera Platforms for Tyrosine Phosphorylation. ACS central science. 2023;9(8):1558-1566. doi:10.1021/acscentsci.3c00200Google ScholarPubMedDOI
McAuley GE, Yiu G, Chang PC, et al. Human T cell generation is restored in CD3δ severe combined immunodeficiency through adenine base editing. Cell. 2023;186(7):1398-1416.e23. doi:10.1016/j.cell.2023.02.027Google ScholarPubMedDOI
Nguyen TM, Sreekanth V, Deb A, et al. Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry. 2023. doi:10.1038/s41557-023-01379-8Google ScholarPubMedDOI