Chemical Biology and Therapeutics Science Program

Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity.

Small JC, Joblin-Mills A, Carbone K, et al. Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity. ACS Chem Biol. 2022. doi:10.1021/acschembio.2c00052Google Scholar DOI PubMed

The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes.

Clemons PA, Bittker JA, Wagner FF, et al. The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes. SLAS Discov. 2021;26(7):855-861. doi:10.1177/24725552211019410Google Scholar DOI PubMed

Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules.

Usanov DL, Chan AI, Maianti JP, Liu DR. Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules. Nat Chem. 2018;10(7):704-714. doi:10.1038/s41557-018-0033-8Google Scholar DOI PubMed

Targeting a Therapy-Resistant Cancer Cell State Using Masked Electrophiles as GPX4 Inhibitors

Eaton JK, Furst L, Ruberto RA, et al. Targeting a Therapy-Resistant Cancer Cell State Using Masked Electrophiles as GPX4 Inhibitors. bioRxiv. 2018. doi:10.1101/376764Google Scholar DOI

A programmable Cas9-serine recombinase fusion protein that operates on DNA sequences in mammalian cells.

Chaikind B, Bessen JL, Thompson DB, Hu JH, Liu DR. A programmable Cas9-serine recombinase fusion protein that operates on DNA sequences in mammalian cells. Nucleic Acids Res. 2016;44(20):9758-9770. doi:10.1093/nar/gkw707Google Scholar DOI PubMed

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.

Kato N, Comer E, Sakata-Kato T, et al. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature. 2016;538(7625):344-349. doi:10.1038/nature19804Google Scholar DOI PubMed

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation.

Dirice E, Walpita D, Vetere A, et al. Inhibition of DYRK1A Stimulates Human β-Cell Proliferation. Diabetes. 2016;65(6):1660-71. doi:10.2337/db15-1127Google Scholar DOI PubMed

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage.

Komor AC, Kim YB, Packer MS, Zuris JA, Liu DR. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature. 2016;533(7603):420-4. doi:10.1038/nature17946Google Scholar DOI PubMed

Continuous evolution of Bacillus thuringiensis toxins overcomes insect resistance.

Badran AH, Guzov VM, Huai Q, et al. Continuous evolution of Bacillus thuringiensis toxins overcomes insect resistance. Nature. 2016;533(7601):58-63. doi:10.1038/nature17938Google Scholar DOI PubMed

Correlating chemical sensitivity and basal gene expression reveals mechanism of action.

Rees MG, Seashore-Ludlow B, Cheah JH, et al. Correlating chemical sensitivity and basal gene expression reveals mechanism of action. Nat Chem Biol. 2016;12(2):109-16. doi:10.1038/nchembio.1986Google Scholar DOI PubMed