Proteomics Platform

IRE1α recognizes a structural motif in cholera toxin to activate an unfolded protein response.

Simpson MS, De Luca H, Cauthorn S, et al. IRE1α recognizes a structural motif in cholera toxin to activate an unfolded protein response. The Journal of cell biology. 2024;223(7). doi:10.1083/jcb.202402062DOI Google Scholar PubMed

Automated single-cell proteomics providing sufficient proteome depth to study complex biology beyond cell type classifications.

Ctortecka C, Clark NM, Boyle B, et al. Automated single-cell proteomics providing sufficient proteome depth to study complex biology beyond cell type classifications. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.01.20.576369DOI Google Scholar PubMed

Clinical Proteomics: A Promise Becoming Reality.

Gillette MA, Jimenez CR, Carr SA. Clinical Proteomics: A Promise Becoming Reality. Molecular & cellular proteomics : MCP. 2024;23(2):100688. doi:10.1016/j.mcpro.2023.100688DOI Google Scholar PubMed

An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing.

Waterbury AL, Kwok HS, Lee C, et al. An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing. Molecular cell. 2024. doi:10.1016/j.molcel.2024.05.017DOI Google Scholar PubMed

SHIFTR enables the unbiased identification of proteins bound to specific RNA regions in live cells.

Aydin J, Gabel A, Zielinski S, et al. SHIFTR enables the unbiased identification of proteins bound to specific RNA regions in live cells. Nucleic acids research. 2024. doi:10.1093/nar/gkae038DOI Google Scholar PubMed

HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery.

Stražar M, Park J, Abelin JG, et al. HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery. Immunity. 2023. doi:10.1016/j.immuni.2023.05.009DOI Google Scholar PubMed

The HLA-II immunopeptidome of SARS-CoV-2.

Weingarten-Gabbay S, Chen DY, Sarkizova S, et al. The HLA-II immunopeptidome of SARS-CoV-2. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.05.26.542482DOI Google Scholar PubMed

Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice.

Farsi Z, Nicolella A, Simmons SK, et al. Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice. Neuron. 2023. doi:10.1016/j.neuron.2023.08.004DOI Google Scholar PubMed

Dynamic mapping of proteome trafficking within and between living cells by TransitID.

Xu W, Cheah J, Xu C, et al. Dynamic mapping of proteome trafficking within and between living cells by TransitID. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.02.07.527548DOI Google Scholar PubMed

Protein phosphatase 1 regulates core PCP signaling.

Song S, Cho B, Weiner AT, et al. Protein phosphatase 1 regulates core PCP signaling. EMBO reports. 2023;24(12):e56997. doi:10.15252/embr.202356997DOI Google Scholar PubMed