Metabolomics Platform

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.

Wieder N, Fried JC, Kim C, et al. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.02.19.529127.PubMed Google Scholar DOI

Human hematopoietic stem cell vulnerability to ferroptosis.

Zhao J, Jia Y, Mahmut D, et al. Human hematopoietic stem cell vulnerability to ferroptosis. Cell. 2023;186(4):732-747.e16. doi:10.1016/j.cell.2023.01.020.PubMed Google Scholar DOI

Plasma proteomic risk markers of incident type 2 diabetes reflect physiologically distinct components of glucose-insulin homeostasis.

Cronjé HT, Mi MY, Austin TR, et al. Plasma proteomic risk markers of incident type 2 diabetes reflect physiologically distinct components of glucose-insulin homeostasis. Diabetes. 2023;72(5):666-73. doi:10.2337/db22-0628.PubMed Google Scholar DOI

Inflammatory Bowel Disease Is Associated With Prediagnostic Perturbances in Metabolic Pathways.

Hua X, Ungaro RC, Petrick LM, et al. Inflammatory Bowel Disease Is Associated With Prediagnostic Perturbances in Metabolic Pathways. Gastroenterology. 2023;164(1):147-150.e2. doi:10.1053/j.gastro.2022.09.007.PubMed Google Scholar DOI

Screening in serum-derived medium reveals differential response to compounds targeting metabolism.

Abbott KL, Ali A, Casalena D, et al. Screening in serum-derived medium reveals differential response to compounds targeting metabolism. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.02.25.529972.PubMed Google Scholar DOI

Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis.

Zhou W, Simic P, Zhou IY, et al. Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis. The Journal of clinical investigation. 2023;133(8). doi:10.1172/JCI164610.PubMed Google Scholar DOI

Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies.

Li X, Quick C, Zhou H, et al. Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies. Nature genetics. 2023;55(1):154-164. doi:10.1038/s41588-022-01225-6.PubMed Google Scholar DOI

Liver-specific FGFR4 knockdown in mice on an HFD increases bile acid synthesis and improves hepatic steatosis.

Moreau F, Brunao BB, Liu X-Y, et al. Liver-specific FGFR4 knockdown in mice on an HFD increases bile acid synthesis and improves hepatic steatosis. Journal of lipid research. 2023;64(2):100324. doi:10.1016/j.jlr.2022.100324.PubMed Google Scholar DOI

Engineered probiotics limit CNS autoimmunity by stabilizing HIF-1α in dendritic cells.

Sanmarco LM, Rone JM, Polonio CM, et al. Engineered probiotics limit CNS autoimmunity by stabilizing HIF-1α in dendritic cells. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.03.17.532101.PubMed Google Scholar DOI

Gut microbiota, circulating inflammatory markers and metabolites, and carotid artery atherosclerosis in HIV infection.

Wang Z, Peters BA, Bryant MK, et al. Gut microbiota, circulating inflammatory markers and metabolites, and carotid artery atherosclerosis in HIV infection. Microbiome. 2023;11(1):119. doi:10.1186/s40168-023-01566-2.PubMed Google Scholar DOI