Metabolomics Platform
Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity. Cell Metab. 2015;22(2):332-43. doi:10.1016/j.cmet.2015.07.005.
Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress. Cell Metab. 2015;22(2):291-303. doi:10.1016/j.cmet.2015.06.021. .
A roadmap for interpreting (13)C metabolite labeling patterns from cells. Curr Opin Biotechnol. 2015;34:189-201. doi:10.1016/j.copbio.2015.02.003.
Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst. Nat Commun. 2015;6:7838. doi:10.1038/ncomms8838.
Cross-sectional examination of metabolites and metabolic phenotypes in uremia. BMC Nephrol. 2015;16:98. doi:10.1186/s12882-015-0100-y.
Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α. Nat Med. 2015;21(6):638-46. doi:10.1038/nm.3868.
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med. 2015;7(288):288ra77. doi:10.1126/scitranslmed.aaa3575.
Distinct metabolomic signatures are associated with longevity in humans. Nat Commun. 2015;6:6791. doi:10.1038/ncomms7791.
Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis. Nat Commun. 2015;6:6498. doi:10.1038/ncomms7498.
Metabolomics of renal venous plasma from individuals with unilateral renal artery stenosis and essential hypertension. J Hypertens. 2015;33(4):836-42. doi:10.1097/HJH.0000000000000470. .
The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes. Cell Host Microbe. 2015;17(2):260-73. doi:10.1016/j.chom.2015.01.001.
Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab. 2015;21(1):65-80. doi:10.1016/j.cmet.2014.12.005.
Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans. Mol Genet Metab. 2015;114(1):73-9. doi:10.1016/j.ymgme.2014.11.010.
HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation. PLoS One. 2015;10(8):e0134465. doi:10.1371/journal.pone.0134465.
5-hydroxymethylcytosine is not present in appreciable quantities in Arabidopsis DNA. G3 (Bethesda). 2014;5(1):1-8. doi:10.1534/g3.114.014670. .
Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. Nat Med. 2014;20(10):1193-8. doi:10.1038/nm.3686.
Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis. Cell. 2014;158(6):1309-23. doi:10.1016/j.cell.2014.07.048.
Identification of small compound biomarkers of pituitary adenoma: a bilateral inferior petrosal sinus sampling study. J Neurointerv Surg. 2014;6(7):541-6. doi:10.1136/neurintsurg-2013-010821.
Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1. Hum Mol Genet. 2014;23(14):3865-74. doi:10.1093/hmg/ddu101.
Rictor/mTORC2 loss in the Myf5 lineage reprograms brown fat metabolism and protects mice against obesity and metabolic disease. Cell Rep. 2014;8(1):256-71. doi:10.1016/j.celrep.2014.06.007.
Knockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling. Sci Rep. 2014;4:5414. doi:10.1038/srep05414.
A systematic survey of lipids across mouse tissues. Am J Physiol Endocrinol Metab. 2014;306(8):E854-68. doi:10.1152/ajpendo.00371.2013.
Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells. Cell Rep. 2014;7(1):27-34. doi:10.1016/j.celrep.2014.02.046.
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Nature. 2014;508(7494):108-12. doi:10.1038/nature13110.
Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156(1-2):317-31. doi:10.1016/j.cell.2013.12.010.
β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab. 2014;19(1):96-108. doi:10.1016/j.cmet.2013.12.003.
A genomic and evolutionary approach reveals non-genetic drug resistance in malaria. Genome Biol. 2014;15(11):511. doi:10.1186/PREACCEPT-1067113631444973.
Meclizine inhibits mitochondrial respiration through direct targeting of cytosolic phosphoethanolamine metabolism. J Biol Chem. 2013;288(49):35387-95. doi:10.1074/jbc.M113.489237.
A plasma long-chain acylcarnitine predicts cardiovascular mortality in incident dialysis patients. J Am Heart Assoc. 2013;2(6):e000542. doi:10.1161/JAHA.113.000542.
Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus. Metabolism. 2013;62(12):1772-8. doi:10.1016/j.metabol.2013.07.003.
Reproducibility of metabolomic profiles among men and women in 2 large cohort studies. Clin Chem. 2013;59(11):1657-67. doi:10.1373/clinchem.2012.199133.
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell. 2013;155(2):397-409. doi:10.1016/j.cell.2013.09.025.
2-Aminoadipic acid is a biomarker for diabetes risk. J Clin Invest. 2013;123(10):4309-17. doi:10.1172/JCI64801.
Metabolite profiles during oral glucose challenge. Diabetes. 2013;62(8):2689-98. doi:10.2337/db12-0754.
A genome-wide association study of the human metabolome in a community-based cohort. Cell Metab. 2013;18(1):130-43. doi:10.1016/j.cmet.2013.06.013.
A combined epidemiologic and metabolomic approach improves CKD prediction. J Am Soc Nephrol. 2013;24(8):1330-8. doi:10.1681/ASN.2012101006.
Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome. Proc Natl Acad Sci U S A. 2013;110(24):E2249-54. doi:10.1073/pnas.1308558110. .
SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell. 2013;23(4):450-63. doi:10.1016/j.ccr.2013.02.024.
PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. Cancer Cell. 2013;23(3):287-301. doi:10.1016/j.ccr.2012.11.020.
Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents. Pediatr Obes. 2013;8(1):52-61. doi:10.1111/j.2047-6310.2012.00087.x.
MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors. Nat Genet. 2013;45(1):104-8. doi:10.1038/ng.2471.
The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis. Mol Cell. 2012;48(6):900-13. doi:10.1016/j.molcel.2012.09.030.
mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell Stem Cell. 2012;11(3):429-39. doi:10.1016/j.stem.2012.06.009.
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science. 2012;336(6084):1040-4. doi:10.1126/science.1218595.
Metabolite profiling identifies pathways associated with metabolic risk in humans. Circulation. 2012;125(18):2222-31. doi:10.1161/CIRCULATIONAHA.111.067827.
Targeted metabolomics. Curr Protoc Mol Biol. 2012;Chapter 30:Unit 30.2.1-24. doi:10.1002/0471142727.mb3002s98. .
Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations. Mol Genet Metab. 2012;105(3):463-71. doi:10.1016/j.ymgme.2011.12.005.
Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction. Proc Natl Acad Sci U S A. 2012;109(8):2931-6. doi:10.1073/pnas.1115813109.
Programming human pluripotent stem cells into white and brown adipocytes. Nat Cell Biol. 2012;14(2):209-19. doi:10.1038/ncb2411.
Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. Chem Biol. 2011;18(12):1602-10. doi:10.1016/j.chembiol.2011.09.016.
A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin. Proc Natl Acad Sci U S A. 2011;108(29):11756-65. doi:10.1073/pnas.1018098108. .
A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like. Mol Cell Biol. 2011;31(13):2696-706. doi:10.1128/MCB.01242-10. .
Metabolite profiles and the risk of developing diabetes. Nat Med. 2011;17(4):448-53. doi:10.1038/nm.2307.
Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. J Clin Invest. 2011;121(4):1402-11. doi:10.1172/JCI44442.
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization. Cancer Cell. 2011;19(3):416-28. doi:10.1016/j.ccr.2011.02.014.
Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2. PLoS One. 2010;5(9). doi:10.1371/journal.pone.0012520. .
Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell. 2010;39(2):171-83. doi:10.1016/j.molcel.2010.06.022.
Metabolite profiling identifies markers of uremia. J Am Soc Nephrol. 2010;21(6):1041-1051. doi:10.1681/ASN.2009111132.
Metabolic signatures of exercise in human plasma. Sci Transl Med. 2010;2(33):33ra37. doi:10.1126/scitranslmed.3001006.
Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis. Nat Biotechnol. 2010;28(3):249-55. doi:10.1038/nbt.1606.
A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells. Proc Natl Acad Sci U S A. 2010;107(4):1571-5. doi:10.1073/pnas.0906039107.
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell. 2010;140(2):280-93. doi:10.1016/j.cell.2009.12.041.