Metabolomics Platform

Tryptophan metabolism, gut microbiota, and carotid artery plaque in women with and without HIV infection.

Luo K, Wang Z, Peters BA, et al. Tryptophan metabolism, gut microbiota, and carotid artery plaque in women with and without HIV infection. AIDS (London, England). 2023. doi:10.1097/QAD.0000000000003596Google Scholar DOI PubMed

APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints.

Yin Z, Rosenzweig N, Kleemann KL, et al. APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints. Nature immunology. 2023. doi:10.1038/s41590-023-01627-6Google Scholar DOI PubMed

Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis.

Zhou W, Simic P, Zhou IY, et al. Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis. The Journal of clinical investigation. 2023;133(8). doi:10.1172/JCI164610Google Scholar DOI PubMed

Sleep duration, plasma metabolites, and obesity and diabetes: a metabolome-wide association study in US women.

Fritz J, Huang T, Depner CM, et al. Sleep duration, plasma metabolites, and obesity and diabetes: a metabolome-wide association study in US women. Sleep. 2023;46(1). doi:10.1093/sleep/zsac226Google Scholar DOI PubMed

Large scale proteomic studies create novel privacy considerations.

Hill AC, Guo C, Litkowski EM, et al. Large scale proteomic studies create novel privacy considerations. Scientific reports. 2023;13(1):9254. doi:10.1038/s41598-023-34866-6Google Scholar DOI PubMed

Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma.

Recto K, Kachroo P, Huan T, et al. Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma. EBioMedicine. 2023;95:104758. doi:10.1016/j.ebiom.2023.104758Google Scholar DOI PubMed

Liver-specific FGFR4 knockdown in mice on an HFD increases bile acid synthesis and improves hepatic steatosis.

Moreau F, Brunao BB, Liu XY, et al. Liver-specific FGFR4 knockdown in mice on an HFD increases bile acid synthesis and improves hepatic steatosis. Journal of lipid research. 2023;64(2):100324. doi:10.1016/j.jlr.2022.100324Google Scholar DOI PubMed

Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma.

Benson MD, Eisman AS, Tahir UA, et al. Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma. Cell metabolism. 2023. doi:10.1016/j.cmet.2023.07.012Google Scholar DOI PubMed

Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank.

Zeleznik OA, Kang JH, Lasky-Su J, et al. Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank. Nature communications. 2023;14(1):2860. doi:10.1038/s41467-023-38466-wGoogle Scholar DOI PubMed

Plasma metabolite profiles associated with the World Cancer Research Fund/American Institute for Cancer Research lifestyle score and future risk of cardiovascular disease and type 2 diabetes.

Rios S, García-Gavilán JF, Babio N, et al. Plasma metabolite profiles associated with the World Cancer Research Fund/American Institute for Cancer Research lifestyle score and future risk of cardiovascular disease and type 2 diabetes. Cardiovascular diabetology. 2023;22(1):252. doi:10.1186/s12933-023-01912-6Google Scholar DOI PubMed