Imaging

Interpreting Image-based Profiles using Similarity Clustering and Single-Cell Visualization.

Garcia-Fossa F, Cruz MC, Haghighi M, et al. Interpreting Image-based Profiles using Similarity Clustering and Single-Cell Visualization. Current protocols. 2023;3(3):e713. doi:10.1002/cpz1.713.PubMed Google Scholar DOI

Predicting reprogramming-related gene expression from cell morphology in human induced pluripotent stem cells.

Wakui T, Negishi M, Murakami Y, et al. Predicting reprogramming-related gene expression from cell morphology in human induced pluripotent stem cells. Molecular biology of the cell. 2023;34(5):ar45. doi:10.1091/mbc.E22-06-0215.PubMed Google Scholar DOI

Reference compounds for characterizing cellular injury in high-content cellular morphology assays.

Dahlin JL, Hua BK, Zucconi BE, et al. Reference compounds for characterizing cellular injury in high-content cellular morphology assays. Nature communications. 2023;14(1):1364. doi:10.1038/s41467-023-36829-x.PubMed Google Scholar DOI

High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly.

Berryer MH, Rizki G, Nathanson A, et al. High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly. eLife. 2023;12. doi:10.7554/eLife.80168.PubMed Google Scholar DOI

High-dimensional gene expression and morphology profiles of cells across 28,000 genetic and chemical perturbations.

Haghighi M, Caicedo JC, Cimini BA, Carpenter AE, Singh S. High-dimensional gene expression and morphology profiles of cells across 28,000 genetic and chemical perturbations. Nat Methods. 2022. doi:10.1038/s41592-022-01667-0.PubMed Google Scholar DOI

Virtual screening for small-molecule pathway regulators by image-profile matching.

Rohban MH, Fuller AM, Tan C, et al. Virtual screening for small-molecule pathway regulators by image-profile matching. Cell Syst. 2022. doi:10.1016/j.cels.2022.08.003.PubMed Google Scholar DOI

A New Image for Cell Sorting.

Filby A, Carpenter AE. A New Image for Cell Sorting. N Engl J Med. 2022;386(18):1755-1758. doi:10.1056/NEJMcibr2200971.PubMed Google Scholar DOI

Predicting drug polypharmacology from cell morphology readouts using variational autoencoder latent space arithmetic.

Chow YL, Singh S, Carpenter AE, Way GP. Predicting drug polypharmacology from cell morphology readouts using variational autoencoder latent space arithmetic. PLoS Comput Biol. 2022;18(2):e1009888. doi:10.1371/journal.pcbi.1009888.PubMed Google Scholar DOI

The new era of quantitative cell imaging-challenges and opportunities.

Bagheri N, Carpenter AE, Lundberg E, Plant AL, Horwitz R. The new era of quantitative cell imaging-challenges and opportunities. Mol Cell. 2022;82(2):241-247. doi:10.1016/j.molcel.2021.12.024.PubMed Google Scholar DOI

In vitro neutrophil migration is associated with inhaled corticosteroid treatment and serum cytokines in pediatric asthma.

Lemmel S, Weckmann M, Wohlers A, et al. In vitro neutrophil migration is associated with inhaled corticosteroid treatment and serum cytokines in pediatric asthma. Front Pharmacol. 2022;13:1021317. doi:10.3389/fphar.2022.1021317.PubMed Google Scholar DOI