Imaging Platform

Cell Painting for cytotoxicity and mode-of-action analysis in primary human hepatocytes.

Ewald JD, Titterton KL, Bäuerle A, et al. Cell Painting for cytotoxicity and mode-of-action analysis in primary human hepatocytes. Cell systems. 2026:101566. doi:10.1016/j.cels.2026.101566DOI Google Scholar PubMed

Counting cells can accurately predict small-molecule bioactivity benchmarks.

Seal S, Dee W, Shah A, et al. Counting cells can accurately predict small-molecule bioactivity benchmarks. Nature communications. 2026. doi:10.1038/s41467-026-68725-5DOI Google Scholar PubMed

The OASIS Consortium: Integrating Multi-Omics Technologies to Transform Chemical Safety Assessment.

Rouquié D, Bender A, Cheah J, et al. The OASIS Consortium: Integrating Multi-Omics Technologies to Transform Chemical Safety Assessment. Toxicological sciences : an official journal of the Society of Toxicology. 2025. doi:10.1093/toxsci/kfaf128DOI Google Scholar PubMed

MIFA: Metadata, Incentives, Formats and Accessibility guidelines to improve the reuse of AI datasets for bioimage analysis.

Zulueta-Coarasa T, Jug F, Mathur A, et al. MIFA: Metadata, Incentives, Formats and Accessibility guidelines to improve the reuse of AI datasets for bioimage analysis. Nature methods. 2025. doi:10.1038/s41592-025-02835-8DOI Google Scholar PubMed

Bead-based approaches for increased sensitivity and multiplexing of CRISPR diagnostics.

Siddiqui SM, Welch NL, Nguyen TG, et al. Bead-based approaches for increased sensitivity and multiplexing of CRISPR diagnostics. Nature biomedical engineering. 2025. doi:10.1038/s41551-025-01498-2DOI Google Scholar PubMed

Alternate dyes for image-based profiling assays.

Sivagurunathan S, Byrne P, Muñoz AF, et al. Alternate dyes for image-based profiling assays. SLAS discovery : advancing life sciences R & D. 2025;36:100268. doi:10.1016/j.slasd.2025.100268DOI Google Scholar PubMed

Morphological map of under- and overexpression of genes in human cells.

Chandrasekaran SN, Alix E, Arevalo J, et al. Morphological map of under- and overexpression of genes in human cells. Nature methods. 2025;22(8):1742-1752. doi:10.1038/s41592-025-02753-9DOI Google Scholar PubMed

Live-cell painting: Image-based profiling in live cells using acridine orange.

Garcia-Fossa F, Moraes-Lacerda T, Rodrigues-da-Silva M, et al. Live-cell painting: Image-based profiling in live cells using acridine orange. Molecular biology of the cell. 2025;36(7):mr7. doi:10.1091/mbc.E24-07-0308DOI Google Scholar PubMed

Combining phenomics with transcriptomics reveals cell-type-specific morphological and molecular signatures of the 22q11.2 deletion.

Tegtmeyer M, Liyanage D, Han Y, et al. Combining phenomics with transcriptomics reveals cell-type-specific morphological and molecular signatures of the 22q11.2 deletion. Nature communications. 2025;16(1):6332. doi:10.1038/s41467-025-61547-xDOI Google Scholar PubMed

Inflammatory macrophages associate with tissue injury and fibrosis in a mouse model of tuberculosis.

Boucau J, Castillo JR, Naidoo T, et al. Inflammatory macrophages associate with tissue injury and fibrosis in a mouse model of tuberculosis. The Journal of infectious diseases. 2025. doi:10.1093/infdis/jiaf361DOI Google Scholar PubMed