Epigenomics

A blueprint for local and distal invasion programs in glioblastoma.

Chanoch-Myers R, Hara T, Greenwald AC, et al. A blueprint for local and distal invasion programs in glioblastoma. Nature communications. 2026. doi:10.1038/s41467-026-70470-8PubMed Google Scholar DOI

A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform.

Jain SU, Williamson KE, Ying AW, et al. A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform. Science (New York, N.Y.). 2026:eaeb3627. doi:10.1126/science.aeb3627PubMed Google Scholar DOI

Nucleotide-resolution mapping of regulatory elements via allelic readout of tiled base editing.

Becerra B, Wittibschlager S, Patel ZM, et al. Nucleotide-resolution mapping of regulatory elements via allelic readout of tiled base editing. Nature communications. 2026. doi:10.1038/s41467-026-69918-8PubMed Google Scholar DOI

Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types.

Mazzocca M, Narducci DN, Grosse-Holz S, Matthias J, Karpova TS, Hansen AS. Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types. Nature structural & molecular biology. 2026. doi:10.1038/s41594-026-01807-6PubMed Google Scholar DOI

Persistent T cell activation and cytotoxicity against glioblastoma following single oncolytic virus treatment in a clinical trial.

Meylan M, Tian Y, Wu L, et al. Persistent T cell activation and cytotoxicity against glioblastoma following single oncolytic virus treatment in a clinical trial. Cell. 2026. doi:10.1016/j.cell.2025.12.055PubMed Google Scholar DOI

Hyperinnervation inhibits organ-level regeneration in mammalian skin.

Tam HT, Peng J, Freeman R, et al. Hyperinnervation inhibits organ-level regeneration in mammalian skin. Cell. 2026. doi:10.1016/j.cell.2026.02.027PubMed Google Scholar DOI

Single-cell multiregion epigenomic rewiring in Alzheimer's disease progression and cognitive resilience.

Liu Z, Zhang S, James BT, et al. Single-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilience. Cell. 2025;188(18):4980-5002.e29. doi:10.1016/j.cell.2025.06.031PubMed Google Scholar DOI

Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomas.

St Laurent JD, Xu GD, Ying AW, et al. Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomas. Nature genetics. 2025. doi:10.1038/s41588-025-02333-9PubMed Google Scholar DOI

Dynamics of microcompartment formation at the mitosis-to-G1 transition.

Goel VY, Aboreden NG, Jusuf JM, et al. Dynamics of microcompartment formation at the mitosis-to-G1 transition. Nature structural & molecular biology. 2025. doi:10.1038/s41594-025-01687-2PubMed Google Scholar DOI

Rapid epigenomic classification of acute leukemia.

Steinicke TL, Benfatto S, Capilla-Guerra MR, et al. Rapid epigenomic classification of acute leukemia. Nature genetics. 2025. doi:10.1038/s41588-025-02321-zPubMed Google Scholar DOI