Gene Regulation Observatory

Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation.

Nomura M, Raviram R, Schiffman JS, et al. Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation. Nature genetics. 2026. doi:10.1038/s41588-026-02642-7PubMed DOI Google Scholar

Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types.

Mazzocca M, Narducci DN, Grosse-Holz S, Matthias J, Karpova TS, Hansen AS. Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types. Nature structural & molecular biology. 2026. doi:10.1038/s41594-026-01807-6PubMed DOI Google Scholar

Nucleotide-resolution mapping of regulatory elements via allelic readout of tiled base editing.

Becerra B, Wittibschlager S, Patel ZM, et al. Nucleotide-resolution mapping of regulatory elements via allelic readout of tiled base editing. Nature communications. 2026. doi:10.1038/s41467-026-69918-8PubMed DOI Google Scholar

Hyperinnervation inhibits organ-level regeneration in mammalian skin.

Tam HT, Peng J, Freeman R, et al. Hyperinnervation inhibits organ-level regeneration in mammalian skin. Cell. 2026. doi:10.1016/j.cell.2026.02.027PubMed DOI Google Scholar

A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform.

Jain SU, Williamson KE, Ying AW, et al. A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform. Science (New York, N.Y.). 2026:eaeb3627. doi:10.1126/science.aeb3627PubMed DOI Google Scholar

Learning cell dynamics with neural differential equations

Vinyard ME, Rasmussen AW, Li R, Klein AM, Getz G. Learning cell dynamics with neural differential equations. Nature Machine Intelligence. 2025;7. doi:10.1038/s42256-025-01150-3DOI Google Scholar

Designing synthetic regulatory elements using the generative AI framework DNA-Diffusion.

DaSilva LF, Senan S, Kribelbauer-Swietek JF, et al. Designing synthetic regulatory elements using the generative AI framework DNA-Diffusion. Nature genetics. 2025. doi:10.1038/s41588-025-02441-6PubMed DOI Google Scholar

DNA methylation insulates genic regions from CTCF loops near nuclear speckles.

Roseman SA, Siegenfeld AP, Lee C, Lue NZ, Waterbury AL, Liau BB. DNA methylation insulates genic regions from CTCF loops near nuclear speckles. eLife. 2025;13. doi:10.7554/eLife.102930PubMed DOI Google Scholar

Coupling CRISPR scanning with targeted chromatin accessibility profiling using a double-stranded DNA deaminase.

Roh H, Shen S, Hu Y, et al. Coupling CRISPR scanning with targeted chromatin accessibility profiling using a double-stranded DNA deaminase. Nature methods. 2025. doi:10.1038/s41592-025-02811-2PubMed DOI Google Scholar

Systematic benchmarking of computational methods to identify spatially variable genes.

Li Z, Patel ZM, Song D, et al. Systematic benchmarking of computational methods to identify spatially variable genes. Genome biology. 2025;26(1):285. doi:10.1186/s13059-025-03731-2PubMed DOI Google Scholar