Psychiatric disease, Brain Health

Pyramidal neurons proportionately alter cortical interneuron subtypes.

Wu SJ, Dai M, Yang SP, et al. Pyramidal neurons proportionately alter cortical interneuron subtypes. Nature. 2026. doi:10.1038/s41586-025-09996-8DOI PubMed Google Scholar

Blocking RAN translation without altering repeat RNAs rescues -related ALS and FTD phenotypes.

Jiang X, Schaeffer L, Patni D, et al. Blocking RAN translation without altering repeat RNAs rescues -related ALS and FTD phenotypes. Science (New York, N.Y.). 2026;391(6785):eadv2600. doi:10.1126/science.adv2600DOI PubMed Google Scholar

Search for a genetic cause of variably protease-sensitive prionopathy.

Lian Y, Kotobelli K, Hall S, et al. Search for a genetic cause of variably protease-sensitive prionopathy. PLoS pathogens. 2025;21(8):e1013343. doi:10.1371/journal.ppat.1013343DOI PubMed Google Scholar

Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus.

Mandell KAP, Simmons SK, Nadig A, et al. Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus. Translational psychiatry. 2025;15(1):345. doi:10.1038/s41398-025-03563-5DOI PubMed Google Scholar

Cassini: streamlined and scalable method for in situ profiling of RNA and protein.

Lapique N, Kim MT, Thom N, Nadaf NM, Pineda J, Macosko EZ. Cassini: streamlined and scalable method for in situ profiling of RNA and protein. Nature communications. 2025;16(1):8747. doi:10.1038/s41467-025-63798-0DOI PubMed Google Scholar

Spatially resolved in situ profiling of mRNA life cycle at transcriptome scale in intact cells and tissues using STARmap PLUS, RIBOmap and TEMPOmap.

Ren J, Zeng H, Huang J, et al. Spatially resolved in situ profiling of mRNA life cycle at transcriptome scale in intact cells and tissues using STARmap PLUS, RIBOmap and TEMPOmap. Nature protocols. 2025. doi:10.1038/s41596-025-01248-3DOI PubMed Google Scholar

Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder.

Song BJ, Ge Y, Nicolella A, et al. Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder. Nature communications. 2025;16(1):10793. doi:10.1038/s41467-025-66504-2DOI PubMed Google Scholar

Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAP-Psychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and Uganda.

Stevenson A, Akena D, Stroud RE, et al. Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAP-Psychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and Uganda. BMJ Open. 2019;9(2):e025469. doi:10.1136/bmjopen-2018-025469DOI PubMed Google Scholar

Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers.

Stein MB, Chen CY, Ursano RJ, et al. Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers. JAMA Psychiatry. 2016;73(7):695-704. doi:10.1001/jamapsychiatry.2016.0350DOI PubMed Google Scholar

A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases.

Han B, Pouget JG, Slowikowski K, et al. A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases. Nat Genet. 2016;48(7):803-10. doi:10.1038/ng.3572DOI PubMed Google Scholar