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Xavier Lab

Bacteroides-Derived Sphingolipids Are Critical for Maintaining Intestinal Homeostasis and Symbiosis.
Brown EM, Ke X, Hitchcock D, et al. Bacteroides-Derived Sphingolipids Are Critical for Maintaining Intestinal Homeostasis and Symbiosis. Cell Host Microbe. 2019;25(5):668-680.e7. doi:10.1016/j.chom.2019.04.002.
Invertible promoters mediate bacterial phase variation, antibiotic resistance, and host adaptation in the gut.
Jiang X, A Hall B, Arthur TD, et al. Invertible promoters mediate bacterial phase variation, antibiotic resistance, and host adaptation in the gut. Science. 2019;363(6423):181-187. doi:10.1126/science.aau5238.
T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation.
Biton M, Haber AL, Rogel N, et al. T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation. Cell. 2018;175(5):1307-1320.e22. doi:10.1016/j.cell.2018.10.008.
Antigen discovery and specification of immunodominance hierarchies for MHCII-restricted epitopes.
Graham DB, Luo C, O'Connell DJ, et al. Antigen discovery and specification of immunodominance hierarchies for MHCII-restricted epitopes. Nat Med. 2018;24(11):1762-1772. doi:10.1038/s41591-018-0203-7.
C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.
Mohanan V, Nakata T, A Desch N, et al. C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. Science. 2018;359(6380):1161-1166. doi:10.1126/science.aan0814.