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Center for the Development of Therapeutics

Molecular basis for substrate recruitment to the PRMT5 methylosome.
Mulvaney KM, Blomquist C, Acharya N, et al. Molecular basis for substrate recruitment to the PRMT5 methylosome. Mol Cell. 2021;81(17):3481-3495.e7. doi:10.1016/j.molcel.2021.07.019.
Coronary Disease Association With ADAMTS7 Is Due to Protease Activity.
Mizoguchi T, MacDonald BT, Bhandary B, et al. Coronary Disease Association With ADAMTS7 Is Due to Protease Activity. Circ Res. 2021;129(4):458-470. doi:10.1161/CIRCRESAHA.121.319163.
SARS-CoV spike proteins can compete for electrolytes in physiological fluids according to structure-based quantum-chemical calculations.
Margiotta E, Guerra CFonseca. SARS-CoV spike proteins can compete for electrolytes in physiological fluids according to structure-based quantum-chemical calculations. Comput Theor Chem. 2021:113392. doi:10.1016/j.comptc.2021.113392.
Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.
McKinney DC, McMillan BJ, Ranaghan MJ, et al. Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction. J Med Chem. 2021. doi:10.1021/acs.jmedchem.1c00507.
The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes.
Clemons PA, Bittker JA, Wagner FF, et al. The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes. SLAS Discov. 2021;26(7):855-861. doi:10.1177/24725552211019410.
PRICKLE2 revisited-further evidence implicating PRICKLE2 in neurodevelopmental disorders.
Bayat A, Iqbal S, Borredy K, et al. PRICKLE2 revisited-further evidence implicating PRICKLE2 in neurodevelopmental disorders. Eur J Hum Genet. 2021;29(8):1235-1244. doi:10.1038/s41431-021-00912-y.
Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
Garvie CW, Wu X, Papanastasiou M, et al. Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase. Nat Commun. 2021;12(1):4375. doi:10.1038/s41467-021-24495-w.
Inhibition of Histone Deacetylases 1, 2, and 3 Enhances Clearance of Cholesterol Accumulation in Niemann-Pick C1 Fibroblasts.
Cruz DL, Pipalia N, Mao S, et al. Inhibition of Histone Deacetylases 1, 2, and 3 Enhances Clearance of Cholesterol Accumulation in Niemann-Pick C1 Fibroblasts. ACS Pharmacol Transl Sci. 2021;4(3):1136-1148. doi:10.1021/acsptsci.1c00033.
Oculocutaneous albinism type 1B associated with a functionally significant tyrosinase gene polymorphism detected with Whole Exome Sequencing.
Mendez R, Iqbal S, Vishnopolska S, et al. Oculocutaneous albinism type 1B associated with a functionally significant tyrosinase gene polymorphism detected with Whole Exome Sequencing. Ophthalmic Genet. 2021;42(3):291-295. doi:10.1080/13816810.2021.1888129.
Critical assessment of protein intrinsic disorder prediction.
Necci M, Piovesan D, Tosatto SCE. Critical assessment of protein intrinsic disorder prediction. Nat Methods. 2021;18(5):472-481. doi:10.1038/s41592-021-01117-3.
Multidose evaluation of 6,710 drug repurposing library identifies potent SARS-CoV-2 infection inhibitors and .
Patten JJ, Keiser PT, Gysi D, et al. Multidose evaluation of 6,710 drug repurposing library identifies potent SARS-CoV-2 infection inhibitors and . bioRxiv. 2021. doi:10.1101/2021.04.20.440626.
Selective modulation of a pan-essential protein as a therapeutic strategy in cancer.
Malone CF, Dharia NV, Kugener G, et al. Selective modulation of a pan-essential protein as a therapeutic strategy in cancer. Cancer Discov. 2021. doi:10.1158/2159-8290.CD-20-1213.
Predicting cell health phenotypes using image-based morphology profiling.
Way GP, Kost-Alimova M, Shibue T, et al. Predicting cell health phenotypes using image-based morphology profiling. Mol Biol Cell. 2021;32(9):995-1005. doi:10.1091/mbc.E20-12-0784.
Multigram Preparation of BRD4780 Enantiomers and Assignment of Absolute Stereochemistry.
Chamberlain BT, Vincent M, Nafie J, Müller P, Greka A, Wagner FF. Multigram Preparation of BRD4780 Enantiomers and Assignment of Absolute Stereochemistry. J Org Chem. 2021;86(5):4281-4289. doi:10.1021/acs.joc.0c02520.
Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney disease.
Sidhom E-H, Kim C, Kost-Alimova M, et al. Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney disease. J Clin Invest. 2021;131(5). doi:10.1172/JCI141380.
Characterization of the GABRB2-Associated Neurodevelopmental Disorders.
Achkar CMEl, Harrer M, Smith L, et al. Characterization of the GABRB2-Associated Neurodevelopmental Disorders. Ann Neurol. 2021;89(3):573-586. doi:10.1002/ana.25985.
Assessing optimal: inequalities in codon optimization algorithms.
Ranaghan MJ, Li JJ, Laprise DM, Garvie CW. Assessing optimal: inequalities in codon optimization algorithms. BMC Biol. 2021;19(1):36. doi:10.1186/s12915-021-00968-8.
Regulation of purine metabolism connects KCTD13 to a metabolic disorder with autistic features.
Madison JM, Duong K, Vieux EF, et al. Regulation of purine metabolism connects KCTD13 to a metabolic disorder with autistic features. iScience. 2021;24(1):101935. doi:10.1016/j.isci.2020.101935.
GSK3α, not GSK3β, drives hippocampal NMDAR-dependent LTD via tau-mediated spine anchoring.
Draffin JE, Sánchez-Castillo C, Fernández-Rodrigo A, et al. GSK3α, not GSK3β, drives hippocampal NMDAR-dependent LTD via tau-mediated spine anchoring. EMBO J. 2021;40(2):e105513. doi:10.15252/embj.2020105513.
Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.
Neggers JE, Paolella BR, Asfaw A, et al. Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. Cell Rep. 2020;33(11):108493. doi:10.1016/j.celrep.2020.108493.
TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41.
Carey KL, Paulus GLC, Wang L, et al. TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41. Cell Rep. 2020;33(6):108371. doi:10.1016/j.celrep.2020.108371.
Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants.
Iqbal S, Pérez-Palma E, Jespersen JB, et al. Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants. Proc Natl Acad Sci U S A. 2020;117(45):28201-28211. doi:10.1073/pnas.2002660117.
Predicting functional effects of missense variants in voltage-gated sodium and calcium channels.
Heyne HO, Baez-Nieto D, Iqbal S, et al. Predicting functional effects of missense variants in voltage-gated sodium and calcium channels. Sci Transl Med. 2020;12(556). doi:10.1126/scitranslmed.aay6848.
Multimodal small-molecule screening for human prion protein binders.
Reidenbach AG, Mesleh MF, Casalena D, et al. Multimodal small-molecule screening for human prion protein binders. J Biol Chem. 2020. doi:10.1074/jbc.RA120.014905.
MISCAST: MIssense variant to protein StruCture Analysis web SuiTe.
Iqbal S, Hoksza D, Pérez-Palma E, et al. MISCAST: MIssense variant to protein StruCture Analysis web SuiTe. Nucleic Acids Res. 2020;48(W1):W132-W139. doi:10.1093/nar/gkaa361.
A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic.
Alimova M, Sidhom E-H, Satyam A, et al. A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic. bioRxiv. 2020. doi:10.1101/2020.06.30.180380.
Cationic zinc is required for factor XII recruitment and activation by stimulated platelets and for thrombus formation in vivo.
Chaudhry SA, Serrata M, Tomczak L, et al. Cationic zinc is required for factor XII recruitment and activation by stimulated platelets and for thrombus formation in vivo. J Thromb Haemost. 2020. doi:10.1111/jth.14964.
Autism-Associated Shank3 Is Essential for Homeostatic Compensation in Rodent V1.
Tatavarty V, Pacheco ATorrado, Kuhnle CGroves, et al. Autism-Associated Shank3 Is Essential for Homeostatic Compensation in Rodent V1. Neuron. 2020;106(5):769-777.e4. doi:10.1016/j.neuron.2020.02.033.
Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome.
McCamphill PK, Stoppel LJ, Senter RK, et al. Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome. Sci Transl Med. 2020;12(544). doi:10.1126/scitranslmed.aam8572.
Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12.
Wu X, Schnitzler GR, Gao GF, et al. Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12. J Biol Chem. 2020;295(11):3431-3446. doi:10.1074/jbc.RA119.011191.
Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling.
Corsello SM, Nagari RT, Spangler RD, et al. Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling. Nat Cancer. 2020;1(2):235-248. doi:10.1038/s43018-019-0018-6.
Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1.
Maben Z, Arya R, Rane D, et al. Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1. J Med Chem. 2020;63(1):103-121. doi:10.1021/acs.jmedchem.9b00293.
Defining the landscape of ATP-competitive inhibitor resistance residues in protein kinases.
Persky NS, Hernandez D, M Carmo D, et al. Defining the landscape of ATP-competitive inhibitor resistance residues in protein kinases. Nat Struct Mol Biol. 2020;27(1):92-104. doi:10.1038/s41594-019-0358-z.
Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35
Atack TC, Raymond DD, Blomquist CA, et al. Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35. ACS Medicinal Chemistry Letters. 2020;11(11):2131-2138.
Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35
Atack TC, Raymond DD, Blomquist CA, et al. Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35. ACS Medicinal Chemistry Letters. 2020;11(11):2131-2138.
Current knowledge of SLC6A1-related neurodevelopmental disorders.
Goodspeed K, Pérez-Palma E, Iqbal S, et al. Current knowledge of SLC6A1-related neurodevelopmental disorders. Brain Commun. 2020;2(2):fcaa170. doi:10.1093/braincomms/fcaa170.
Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro.
Algate K, Haynes D, Fitzsimmons T, et al. Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro. J Cell Biochem. 2020;121(1):244-258. doi:10.1002/jcb.29137.
Roles of glycogen synthase kinase 3 alpha and calcineurin in regulating the ability of sperm to fertilize eggs.
Dey S, Eisa A, Kline D, Wagner FF, Abeysirigunawardena S, Vijayaraghavan S. Roles of glycogen synthase kinase 3 alpha and calcineurin in regulating the ability of sperm to fertilize eggs. FASEB J. 2020;34(1):1247-1269. doi:10.1096/fj.201902163R.
Characterization of the Prion Protein Binding Properties of Antisense Oligonucleotides.
Reidenbach AG, Minikel EVallabh, Zhao HT, et al. Characterization of the Prion Protein Binding Properties of Antisense Oligonucleotides. Biomolecules. 2019;10(1). doi:10.3390/biom10010001.
Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation.
Subramanian A, Sidhom E-H, Emani M, et al. Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation. Nat Commun. 2019;10(1):5462. doi:10.1038/s41467-019-13382-0.
Optimization of PDE3A Modulators for SLFN12-Dependent Cancer Cell Killing.
Lewis TA, de Waal L, Wu X, et al. Optimization of PDE3A Modulators for SLFN12-Dependent Cancer Cell Killing. ACS Med Chem Lett. 2019;10(11):1537-1542. doi:10.1021/acsmedchemlett.9b00360.
Structural basis for the docking of mTORC1 on the lysosomal surface.
Rogala KB, Gu X, Kedir JF, et al. Structural basis for the docking of mTORC1 on the lysosomal surface. Science. 2019;366(6464):468-475. doi:10.1126/science.aay0166.
The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies.
Christian S, Merz C, Evans L, et al. The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies. Leukemia. 2019;33(10):2403-2415. doi:10.1038/s41375-019-0461-5.
Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers.
Sulahian R, Kwon JJ, Walsh KH, et al. Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers. Cell Rep. 2019;29(1):118-134.e8. doi:10.1016/j.celrep.2019.08.090.
Chasing Tails: Cathepsin-L Improves Structural Analysis of Histones by HX-MS.
Papanastasiou M, Mullahoo J, DeRuff KC, et al. Chasing Tails: Cathepsin-L Improves Structural Analysis of Histones by HX-MS. Mol Cell Proteomics. 2019;18(10):2089-2098. doi:10.1074/mcp.RA119.001325.
Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy.
Dvela-Levitt M, Kost-Alimova M, Emani M, et al. Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy. Cell. 2019;178(3):521-535.e23. doi:10.1016/j.cell.2019.07.002.
Conservation of the structure and function of bacterial tryptophan synthases.
Michalska K, Gale J, Joachimiak G, et al. Conservation of the structure and function of bacterial tryptophan synthases. IUCrJ. 2019;6(Pt 4):649-664. doi:10.1107/S2052252519005955.
Discovering metabolic disease gene interactions by correlated effects on cellular morphology.
Jiao Y, Ahmed U, Sim MFMichelle, et al. Discovering metabolic disease gene interactions by correlated effects on cellular morphology. Mol Metab. 2019;24:108-119. doi:10.1016/j.molmet.2019.03.001.
Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription.
Struntz NB, Chen A, Deutzmann A, et al. Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription. Cell Chem Biol. 2019;26(5):711-723.e14. doi:10.1016/j.chembiol.2019.02.009.
Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers.
Price C, Gill S, Ho ZV, et al. Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers. Cancer Res. 2019;79(10):2564-2579. doi:10.1158/0008-5472.CAN-18-2674.
A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9.
Maji B, Gangopadhyay SA, Lee M, et al. A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9. Cell. 2019;177(4):1067-1079.e19. doi:10.1016/j.cell.2019.04.009.
Publisher Correction: Side chain determinants of biopolymer function during selection and replication.
Lichtor PA, Chen Z, Elowe NH, Chen JC, Liu DR. Publisher Correction: Side chain determinants of biopolymer function during selection and replication. Nat Chem Biol. 2019;15(5):550. doi:10.1038/s41589-019-0254-1.
Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias.
Hinze L, Pfirrmann M, Karim S, et al. Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias. Cancer Cell. 2019;35(4):664-676.e7. doi:10.1016/j.ccell.2019.03.004.
A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.
Zou Y, Palte MJ, Deik AA, et al. A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis. Nat Commun. 2019;10(1):1617. doi:10.1038/s41467-019-09277-9.
WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
Chan EM, Shibue T, McFarland JM, et al. WRN helicase is a synthetic lethal target in microsatellite unstable cancers. Nature. 2019;568(7753):551-556. doi:10.1038/s41586-019-1102-x.
Crystal structure of MICU2 and comparison with MICU1 reveal insights into the uniporter gating mechanism.
Kamer KJ, Jiang W, Kaushik VK, Mootha VK, Grabarek Z. Crystal structure of MICU2 and comparison with MICU1 reveal insights into the uniporter gating mechanism. Proc Natl Acad Sci U S A. 2019;116(9):3546-3555. doi:10.1073/pnas.1817759116.
Development of a novel, sensitive cell-based corin assay.
Lambertz P, Theisen L, Längst N, et al. Development of a novel, sensitive cell-based corin assay. Biochem Pharmacol. 2019;160:62-70. doi:10.1016/j.bcp.2018.12.009.
Glycogen synthase kinase 3-β inhibition induces lymphangiogenesis through β-catenin-dependent and mTOR-independent pathways.
Stump B, Shrestha S, Lamattina AM, et al. Glycogen synthase kinase 3-β inhibition induces lymphangiogenesis through β-catenin-dependent and mTOR-independent pathways. PLoS One. 2019;14(4):e0213831. doi:10.1371/journal.pone.0213831.
Novel tricyclic glycal-based inducers that reprogram LDL metabolism in hepatic cells.
Nagiec MM, Duvall JR, Skepner AP, et al. Novel tricyclic glycal-based inducers that reprogram LDL metabolism in hepatic cells. Medchemcomm. 2018;9(11):1831-1842. doi:10.1039/c8md00297e.
High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth.
Radke JB, Carey KL, Shaw S, et al. High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth. ACS Infect Dis. 2018;4(10):1499-1507. doi:10.1021/acsinfecdis.8b00135.
High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding.
Chiang W-C, Wei Y, Kuo Y-C, et al. High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding. ACS Chem Biol. 2018;13(8):2247-2260. doi:10.1021/acschembio.8b00421.
Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules.
Usanov DL, Chan AI, Maianti JPablo, Liu DR. Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules. Nat Chem. 2018;10(7):704-714. doi:10.1038/s41557-018-0033-8.
Functionally Biased D2R Antagonists: Targeting the β-Arrestin Pathway to Improve Antipsychotic Treatment.
Weïwer M, Xu Q, Gale JP, et al. Functionally Biased D2R Antagonists: Targeting the β-Arrestin Pathway to Improve Antipsychotic Treatment. ACS Chem Biol. 2018;13(4):1038-1047. doi:10.1021/acschembio.8b00168.
Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.
Wagner FF, Benajiba L, Campbell AJ, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018;10(431). doi:10.1126/scitranslmed.aam8460.
Targeting a Therapy-Resistant Cancer Cell State Using Masked Electrophiles as GPX4 Inhibitors
Eaton JK, Furst L, Ruberto RA, et al. Targeting a Therapy-Resistant Cancer Cell State Using Masked Electrophiles as GPX4 Inhibitors. bioRxiv. 2018. doi:10.1101/376764.
The Autophagy-Related Beclin-1 Protein Requires the Coiled-Coil and BARA Domains To Form a Homodimer with Submicromolar Affinity.
Ranaghan MJ, Durney MA, Mesleh MF, et al. The Autophagy-Related Beclin-1 Protein Requires the Coiled-Coil and BARA Domains To Form a Homodimer with Submicromolar Affinity. Biochemistry. 2017;56(51):6639-6651. doi:10.1021/acs.biochem.7b00936.
Genomic Activation of Reveals a Candidate Therapeutic Axis in Bladder Cancer.
Goldstein JT, Berger AC, Shih J, et al. Genomic Activation of Reveals a Candidate Therapeutic Axis in Bladder Cancer. Cancer Res. 2017;77(24):6987-6998. doi:10.1158/0008-5472.CAN-17-1701.
A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay.
Bray M-A, Gustafsdottir SM, Rohban MH, et al. A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay. Gigascience. 2017;6(12):1-5. doi:10.1093/gigascience/giw014.
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.
Subramanian A, Narayan R, Corsello SM, et al. A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles. Cell. 2017;171(6):1437-1452.e17. doi:10.1016/j.cell.2017.10.049.
Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.
Johannessen, iv L, Sundberg TB, O'Connell DJ, et al. Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat Chem Biol. 2017;13(10):1102-1108. doi:10.1038/nchembio.2458.
Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine.
Geller LT, Barzily-Rokni M, Danino T, et al. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017;357(6356):1156-1160. doi:10.1126/science.aah5043.
Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease.
Klarin D, Zhu QMartin, Emdin CA, et al. Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease. Nat Genet. 2017;49(9):1392-1397. doi:10.1038/ng.3914.
A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.
Wellington S, Nag PP, Michalska K, et al. A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. Nat Chem Biol. 2017;13(9):943-950. doi:10.1038/nchembio.2420.
Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile.
Duvall JR, Bedard L, Naylor-Olsen AM, et al. Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile. ACS Infect Dis. 2017;3(5):349-359. doi:10.1021/acsinfecdis.6b00206.
The Drug Repurposing Hub: a next-generation drug library and information resource.
Corsello SM, Bittker JA, Liu Z, et al. The Drug Repurposing Hub: a next-generation drug library and information resource. Nat Med. 2017;23(4):405-408. doi:10.1038/nm.4306.
Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.
Sharabi K, Lin H, Tavares CDJ, et al. Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes. Cell. 2017;169(1):148-160.e15. doi:10.1016/j.cell.2017.03.001.
High Throughput Screening Methods: Evolution and Refinement
Bittker JA, Ross NT. High Throughput Screening Methods: Evolution and Refinement. Royal Society of Chemistry; 2017. doi:10.1039/9781782626770.
Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia.
Lewis TA, Sykes DB, Law JM, et al. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett. 2016;7(12):1112-1117. doi:10.1021/acsmedchemlett.6b00316.
Structural and conformational determinants of macrocycle cell permeability.
Over B, Matsson P, Tyrchan C, et al. Structural and conformational determinants of macrocycle cell permeability. Nat Chem Biol. 2016;12(12):1065-1074. doi:10.1038/nchembio.2203.
Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells.
Lopez-Sambrooks C, Shrimal S, Khodier C, et al. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat Chem Biol. 2016;12(12):1023-1030. doi:10.1038/nchembio.2194.
RNF166 Determines Recruitment of Adaptor Proteins during Antibacterial Autophagy.
Heath RJ, Goel G, Baxt LA, et al. RNF166 Determines Recruitment of Adaptor Proteins during Antibacterial Autophagy. Cell Rep. 2016;17(9):2183-2194. doi:10.1016/j.celrep.2016.11.005.
Point mutations at the catalytic site of PCSK9 inhibit folding, autoprocessing, and interaction with the LDL receptor.
Garvie CW, Fraley CV, Elowe NH, et al. Point mutations at the catalytic site of PCSK9 inhibit folding, autoprocessing, and interaction with the LDL receptor. Protein Sci. 2016;25(11):2018-2027. doi:10.1002/pro.3019.
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.
Kato N, Comer E, Sakata-Kato T, et al. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature. 2016;538(7625):344-349. doi:10.1038/nature19804.
Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1.
Law JM, Stark SC, Liu K, et al. Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1. ACS Med Chem Lett. 2016;7(10):944-949. doi:10.1021/acsmedchemlett.6b00264.
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.
Sykes DB, Kfoury YS, Mercier FE, et al. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell. 2016;167(1):171-186.e15. doi:10.1016/j.cell.2016.08.057.
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.
Wagner FF, Weïwer M, Steinbacher S, et al. Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorg Med Chem. 2016;24(18):4008-4015. doi:10.1016/j.bmc.2016.06.040.
Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes.
Bray M-A, Singh S, Han H, et al. Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes. Nat Protoc. 2016;11(9):1757-74. doi:10.1038/nprot.2016.105.
Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting.
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