Center for the Development of Therapeutics

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.

Wieder N, Fried JC, Kim C, et al. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.02.19.529127.DOI Google Scholar PubMed

Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists.

Orsi D, Ferrara S, Siegel S, et al. Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists. Bioorganic & medicinal chemistry. 2023;78:117130. doi:10.1016/j.bmc.2022.117130.DOI Google Scholar PubMed

Delineation of functionally essential protein regions for 242 neurodevelopmental genes.

Iqbal S, Brünger T, Pérez-Palma E, et al. Delineation of functionally essential protein regions for 242 neurodevelopmental genes. Brain : a journal of neurology. 2023;146(2):519-533. doi:10.1093/brain/awac381.DOI Google Scholar PubMed

High-Throughput Neutralization and Serology Assays Reveal Correlated but Highly Variable Humoral Immune Responses in a Large Population of Individuals Infected with SARS-CoV-2 in the US between March and August 2020.

Zhang S, Ma P, Orzechowski M, et al. High-Throughput Neutralization and Serology Assays Reveal Correlated but Highly Variable Humoral Immune Responses in a Large Population of Individuals Infected with SARS-CoV-2 in the US between March and August 2020. mBio. 2023:e0352322. doi:10.1128/mbio.03523-22.DOI Google Scholar PubMed

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.

Wieder N, Fried J, Kim C, et al. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. Cell metabolism. 2023. doi:10.1016/j.cmet.2023.03.018.DOI Google Scholar PubMed

Velcrin-induced selective cleavage of tRNA(TAA) by SLFN12 causes cancer cell death.

Lee S, Hoyt S, Wu X, et al. Velcrin-induced selective cleavage of tRNA(TAA) by SLFN12 causes cancer cell death. Nat Chem Biol. 2022. doi:10.1038/s41589-022-01170-9.DOI Google Scholar PubMed

Virtual screening for small-molecule pathway regulators by image-profile matching.

Rohban MH, Fuller AM, Tan C, et al. Virtual screening for small-molecule pathway regulators by image-profile matching. Cell Syst. 2022. doi:10.1016/j.cels.2022.08.003.DOI Google Scholar PubMed

Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy.

Chaffin M, Papangeli I, Simonson B, et al. Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy. Nature. 2022. doi:10.1038/s41586-022-04817-8.DOI Google Scholar PubMed

RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.

Fang L, Ford-Roshon D, Russo M, et al. RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition. Nat Commun. 2022;13(1):3181. doi:10.1038/s41467-022-30794-7.DOI Google Scholar PubMed

Protein Flexibility and Dissociation Pathway Differentiation Can Explain Onset Of Resistance Mutations in Kinases.

Shekhar M, Smith Z, Seeliger M, Tiwary P. Protein Flexibility and Dissociation Pathway Differentiation Can Explain Onset Of Resistance Mutations in Kinases. Angew Chem Int Ed Engl. 2022. doi:10.1002/anie.202200983.DOI Google Scholar PubMed