Center for the Development of Therapeutics

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.

Wieder N, Fried JC, Kim C, et al. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.02.19.529127Google Scholar PubMed DOI

Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists.

Orsi D, Ferrara S, Siegel S, et al. Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists. Bioorganic & medicinal chemistry. 2023;78:117130. doi:10.1016/j.bmc.2022.117130Google Scholar PubMed DOI

Delineation of functionally essential protein regions for 242 neurodevelopmental genes.

Iqbal S, Brünger T, Pérez-Palma E, et al. Delineation of functionally essential protein regions for 242 neurodevelopmental genes. Brain : a journal of neurology. 2023;146(2):519-533. doi:10.1093/brain/awac381Google Scholar PubMed DOI

High-Throughput Neutralization and Serology Assays Reveal Correlated but Highly Variable Humoral Immune Responses in a Large Population of Individuals Infected with SARS-CoV-2 in the US between March and August 2020.

Zhang S, Ma P, Orzechowski M, et al. High-Throughput Neutralization and Serology Assays Reveal Correlated but Highly Variable Humoral Immune Responses in a Large Population of Individuals Infected with SARS-CoV-2 in the US between March and August 2020. mBio. 2023:e0352322. doi:10.1128/mbio.03523-22Google Scholar PubMed DOI

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.

Wieder N, Fried J, Kim C, et al. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. Cell metabolism. 2023. doi:10.1016/j.cmet.2023.03.018Google Scholar PubMed DOI

Velcrin-induced selective cleavage of tRNA(TAA) by SLFN12 causes cancer cell death.

Lee S, Hoyt S, Wu X, et al. Velcrin-induced selective cleavage of tRNA(TAA) by SLFN12 causes cancer cell death. Nat Chem Biol. 2022. doi:10.1038/s41589-022-01170-9Google Scholar PubMed DOI

Virtual screening for small-molecule pathway regulators by image-profile matching.

Rohban MH, Fuller AM, Tan C, et al. Virtual screening for small-molecule pathway regulators by image-profile matching. Cell Syst. 2022. doi:10.1016/j.cels.2022.08.003Google Scholar PubMed DOI

Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy.

Chaffin M, Papangeli I, Simonson B, et al. Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy. Nature. 2022. doi:10.1038/s41586-022-04817-8Google Scholar PubMed DOI

RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.

Fang L, Ford-Roshon D, Russo M, et al. RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition. Nat Commun. 2022;13(1):3181. doi:10.1038/s41467-022-30794-7Google Scholar PubMed DOI

Protein Flexibility and Dissociation Pathway Differentiation Can Explain Onset Of Resistance Mutations in Kinases.

Shekhar M, Smith Z, Seeliger M, Tiwary P. Protein Flexibility and Dissociation Pathway Differentiation Can Explain Onset Of Resistance Mutations in Kinases. Angew Chem Int Ed Engl. 2022. doi:10.1002/anie.202200983Google Scholar PubMed DOI