Center for the Development of Therapeutics

Gomez JE, Solomon MY, Hunt DK, et al. Large-Scale Chemical-Genetic Interaction Profiling Identifies a Small-Molecule Inhibitor of Mycobacterium tuberculosis Polyketide Synthase 13. ACS infectious diseases. 2026. doi:10.1021/acsinfecdis.6c00136Google ScholarPubMedDOI

Meng Z, Bai Z, Yuan K, et al. Explainable Physicochemical Determinants of Protein-Ligand Binding via Non-Covalent Interactions. bioRxiv : the preprint server for biology. 2026. doi:10.64898/2026.03.03.707476Google ScholarPubMedDOIPubMed Central

Yin X, Bickerton C, MacDonald B, et al. Loss of Mtarc1 Protects Against Steatotic Liver Disease in Mice. Liver international : official journal of the International Association for the Study of the Liver. 2026;46(2):e70507. doi:10.1111/liv.70507Google ScholarPubMedDOI

van Tienen LM, Bayoumi S, Muneeruddin K, et al. Systematic cysteine scanning identifies a druggable pocket in oncogenic KRAS. Cell chemical biology. 2026. doi:10.1016/j.chembiol.2026.01.007Google ScholarPubMedDOI

Ellis H, Balasooriya ER, Varkaris A, et al. Mechanisms of Clinical Resistance to Selective FGFR2 Inhibition by Lirafugratinib. Annals of oncology : official journal of the European Society for Medical Oncology. 2026. doi:10.1016/j.annonc.2026.01.004Google ScholarPubMedDOI

Rush JS, Wertheimer JD, Goldberg SD, et al. Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity. Cell. 2026. doi:10.1016/j.cell.2025.12.013Google ScholarPubMedDOI

Haj AK, Paul DS, Jurgens SJ, et al. Coagulation factor XII haploinsufficiency is protective against venous thromboembolism in a population-scale multidimensional analysis. Nature communications. 2025;16(1):8176. doi:10.1038/s41467-025-62789-5Google ScholarPubMedDOI

Rouquié D, Bender A, Cheah J, et al. The OASIS Consortium: Integrating Multi-Omics Technologies to Transform Chemical Safety Assessment. Toxicological sciences : an official journal of the Society of Toxicology. 2025. doi:10.1093/toxsci/kfaf128Google ScholarPubMedDOI

Krishnan A. A generative deep learning approach to de novo antibiotic design. Cell. 2025. doi:10.1016/j.cell.2025.07.033Google ScholarPubMedDOI

Samokhin AO, Seo HS, Leed A, et al. Targeting NEDD9-SH3 with a Covalent Peptide Controls Endothelial Phenotype. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.07.10.663547Google ScholarPubMedDOI