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Psychiatric Disease

The Stanley Center’s primary scientific focus is on the severe psychiatric disorders schizophrenia, bipolar disorder, and autism, and the frequently comorbid neurodevelopmental disorder, attention deficit hyperactivity disorder (ADHD). These illnesses have dire consequences for individuals, families, and societies. Fortunately, they have begun to be scientifically tractable because new genomic and computational tools have made it possible to exploit their high heritabilities. We study these disorders because they exhibit significant sharing of genetic risk variants and because their pathogenesis occurs against the shared backdrop of brain development. In addition, at this early stage, the scientific approaches to gene identification and to mechanistic follow-on studies utilize identical and often scalable methodologies.