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Use of Salt-Inducible Kinase (SIK) Inhibitors for Treating Osteoporosis

Application No.

PCT/US2017/051937

Broad Case No.

BI-10245

List of inventors -

Marc Wein, Henry Kronenberg, Tom Sundberg, Ramnik Xavier

Abstract

The present disclosure provides methods of treating and/or preventing osteoporosis using salt-inducible kinase (SIK) inhibitors. Also provided are methods of using SIK inhibitors for increasing the function of osteocytes, increasing the number of osteoblasts, increasing the activity of osteoblasts, inhibiting the resorption of a bone, decreasing the number of osteoclasts, inhibiting the activity of osteoclasts, increasing the mass of a bone, down-regulating the expression of the gene SOST, and/or inhibiting the activity of sclerostin. The SIK inhibitors may be combined with Src inhibitors or CSF I R inhibitors. Exemplary SIK inhibitors include the compounds of the formula: (I), (II), (III), (IV), (V) or (VI).

Date PUBLISHED

  • 03/22/2018

Published Patent Application

  • WO2018/053373

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