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Systems and Methods for Predicting Repair Outcomes in Genetic Engineering

Application No.

PCT/US2018/065886

Broad Case No.

BI-10350

List of inventors -

Mandana Arbab, David Gifford, Jonathan Hsu, David Liu, Max Shen, Richard Sherwood

Abstract

The specification provides methods for introducing a desired genetic change in a nucleotide sequence using a double-strand break (DSB)-inducing genome editing system, the method comprising: identifying one or more available cut sites in a nucleotide sequence; analyzing the nucleotide sequence and available cut sites with a computational model to identify the optimal cut site for introducing the desired genetic change into the nucleotide sequence; and contacting the nucleotide sequence with a DSB-inducing genome editing system, thereby introducing the desired genetic change in the nucleotide sequence at the cut site.

Date PUBLISHED

  • 06/20/2019

Published Patent Application

  • WO2019/118949

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