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Novel Nucleic Acid Modifiers

Application No.

PCT/US2018/057182

Broad Case No.

BI-10143

List of inventors -

Amit Choudhary, Kurt Cox, Soumyashree Gangopadhyay, Donghyun Lim

Abstract

The present inventions generally relate to site-specific delivery of nucleic acid modifiers and includes novel DNA-binding proteins and effectors that can be rapidly programmed to make site-specific DNA modifications. The present inventions also provide a synthetic all-in-one genome editor (SAGE) systems comprising designer DNA sequence readers and a set of small molecules that induce double-strand breaks, enhance cellular permeability, inhibit NHEJ and activate HDR, as well as methods of using and delivering such systems.

Date PUBLISHED

  • 07/11/2019

Published Patent Application

  • WO2019/135816

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