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Methods of identifying drug-modulated polypeptide targets for degradation

Application No.

PCT/US2016/051035

Broad Case No.

BI-2015/060

List of inventors -

Benjamin Ebert, Tarjei Mikkelsen, Quinlan Sievers

Abstract

In one aspect, the invention features a method for identifying a drug-modulated polypeptide substrate of cereblon (CRBN). In another aspect, the invention features a method of identifying a polypeptide target of a modulator of CRBN. In yet another aspect, the invention provides methods of monitoring or characterizing the sensitivity of a subject to a modulator of CRBN.

Date PUBLISHED

  • 03/16/2017

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