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Methods for High-Resolution Genome-Wide Functional Dissection of Transcriptional Regulatory Regions

Application No.

PCT/US2018/056371

Broad Case No.

BI-10262

List of inventors -

Melina Claussnitzer, Liang He, Manolis Kellis, Xinchen Wang

Abstract

Embodiments disclosed herein provide a general, scalable, high-throughput, and high-resolution approach for experimental dissection of regulatory regions and driver nucleotides in the context of human biology and disease. Applicants present HiDRA, a novel high-resolution global screen for transcriptional regulatory activity in accessible chromatin regions, enabling high-efficiency, high-throughput, and high-resolution inference of regulatory activity.

Date PUBLISHED

  • 04/25/2019

Published Patent Application

  • WO2019/079514

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