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Methods and Compositions for Targeting Developmental and Oncogenic Programs in H3K27M Gliomas

Application No.

PCT/US2018/060799

Broad Case No.

BI-10276

List of inventors -

Bradley Bernstein, Mariella Filbin, Volker Hovestadt, Aviv Regev, Mario Suva, Itay Tirosh

Abstract

The subject matter disclosed herein is generally directed to compositions and methods for treating diffuse gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-gliomas). Disclosed herein are gene signatures specific for tumor cell types and compositions for treatment of H3K27M gliomas. In one embodiment, PRC1 is targeted in a treatment regimen for H3K27M-gliomas.

Date PUBLISHED

  • 05/16/2019

Published Patent Application

  • WO2019/094955

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