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Methods and Compositions for Modulating Suppression of Lymphocyte Activity

Application No.


Broad Case No.


List of inventors -

Ana Anderson, Vijay Kuchroo, Aviv Regev, Meromit Singer


The subject matter disclosed herein is generally directed to a novel CD8+ T cell subtype associated with suppressive or regulatory T cell functions. Moreover, the subject matter disclosed herein is generally directed to methods and compositions for use of the subtype. Also, disclosed herein are gene signatures and markers associated with the subtype and use of said signatures and markers. Further disclosed are therapeutic methods of using said gene signatures and immune cell subtype. Further disclosed are pharmaceutical compositions comprising populations of CD8+ TILs depleted for a specific subtype. Further disclosed are interactions with other T cell subtypes.


  • 04/04/2019

Published Patent Application

  • WO2019/068099

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