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Methods and Compositions for Modulating Immune Responses and Lymphocyte Activity

Application No.

PCT/US2018/061812

Broad Case No.

BI-10258

List of inventors -

Ana Anderson, Vijay Kuchroo, Aviv Regev, Meromit Singer

Abstract

The subject matter disclosed herein is generally directed to novel CD8+ and CD4+ T cell subtypes associated with effector, suppressive or regulatory T cell functions. Moreover, the subject matter disclosed herein is generally directed to methods and compositions for use of the subtype. Also, disclosed herein are gene signatures and markers associated with the subtype and use of said signatures and markers. Further disclosed are therapeutic methods of using said gene signatures and immune cell subtype. Further disclosed are pharmaceutical compositions comprising populations of CD4+ and/or CD8+ TILs or populations of immune cells depleted for a specific subtype. Further disclosed are interactions with other T cell subtypes.

Date PUBLISHED

  • 05/23/2019

Published Patent Application

  • WO2019/100001

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