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Methods and Compositions for Determination of Mutations in Single Replication Events

Application No.

PCT/US2018/032157

Broad Case No.

BI-10195

List of inventors -

Paul Blainey, Yehuda Brody, Soohong Kim, Robert Kimmerling

Abstract

Most somatic mutations are harmless, but some lead to a phenotypic consequence. The present invention provides methods and tools to elucidate exactly how mutations appear in the genome using detection of mutations in a cell lineage. The present invention also provides for determining the effect of environmental stimuli and drugs on somatic mutations. Finally, the present invention provides for personalized medicine by determining the effect of drugs on somatic mutations in cells obtained from a subject in need thereof.

Date PUBLISHED

  • 11/15/2018

Published Patent Application

  • WO2018/209145

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