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Methods and Compositions for Altering Function and Structure of Chromatin Loops and/or Domains

Application No.

PCT/US2018/054476

Broad Case No.

BI-10265

List of inventors -

Erez Aiden, Su-Chen Huang, Eric S Lander, Suhas Rao

Abstract

Chromatin 3D stucture modulating agents in the context of the present invention are intended to interfere or manipulate the function of loop anchor motifs, such as CTCF motifs. In certain example embodiments, the present invention may block formation of all or essentially all loop anchor or chromatin domains or block formation of a loop anchor or chromatin domain at a targeted genomic location. For instance, the chromatin 3D structure modulating agent may bind a target region and mask a loop anchor motif, thereby preventing a loop anchor or chromatin domain from forming. The chromatin 3D structure modulating agent may bind a target region and cause a loop anchor of chromatin domain to form.

Date PUBLISHED

  • 04/11/2019

Published Patent Application

  • WO2019/071054

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