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Markers of Active HIV Reservoir

Application No.

PCT/US2018/056167

Broad Case No.

BI-10272

List of inventors -

Alexander Shalek, Carly Ziegler

Abstract

Embodiments disclosed herein provide a pan-tissue cell atlas of healthy and diseased subjects obtained by single cell sequencing. The present invention discloses novel markers for cell types. Moreover, genes associated with disease, including HIV infection and tuberculosis are identified. The invention provides for diagnostic assays based on gene markers and cell composition, as well as therapeutic targets for controlling immune regulations and cell-cell communication of the cell types disclosed herein. In addition, novel cell types and methods of quantitating, detecting and isolating the cell types are disclosed.

Date PUBLISHED

  • 04/25/2019

Published Patent Application

  • WO2019/079361

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