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IL-8, IL-6, IL-1 Beta and Tet2 and DNMT3A in Atherosclerosis

Application No.

PCT/US2018/029098

Broad Case No.

BI-10150

List of inventors -

Benjamin Ebert, Siddhartha Jaiswal, Sekar Kathiresan

Abstract

The application presently discloses a method of treating atherosclerosis in a human subject comprising administering an effective amount of an IL-8 inhibitor, an IL-6 inhibitor, and/or an IL-1β inhibitor, wherein the subject has a TET2 and/or DNMT3A mutation thereby treating atherosclerosis. It also discloses a method for treating atherosclerosis in a human subject comprising sequencing at least a part of a genome comprising TET2 and/or DNMT3A of one or more cells in a blood sample of the subject; determining from the sequencing whether the subject has one or more mutations in TET2 and/or DNMT3A, if it is determined that the subject has at least one TET2 and/or DNMT3A mutation, administering an IL-8 inhibitor, an IL-6 inhibitor, and/or an IL-1β inhibitor to a subject to the subject thereby treating atherosclerosis.

Date PUBLISHED

  • 11/01/2018

Published Patent Application

  • WO2018/200489

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