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Gut Microbiome Function Predicts Response to Anti-Integrin Biologic Therapy in Inflammatory Bowel Diseases

Application No.

PCT/US2018/031793

Broad Case No.

BI-10196

List of inventors -

Ashwin Ananthakrishnan, Chengwei Luo, Ramnik Xavier, Vijay Yajnik

Abstract

The present invention relates to a relationship between microbial metagenomic structure and function and clinical remission with anti-integrin therapy induction; longitudinal trajectory of changes in the microbiome with maintenance treatment; and a comprehensive predictive model incorporating clinical and microbiome-related data to accurately classify treatment response.

Date PUBLISHED

  • 11/15/2018

Published Patent Application

  • WO2018/208910

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