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CRISPR Protein Inhibitors

Application No.


Broad Case No.


List of inventors -

Amit Choudhary, Kurt Cox, Elisa Franco, Basudeb Maji, Hari Subramanian, Peng Wu


The embodiments disclosed herein utilize fluorescence polarization based preliminary screen to identify a putative set of Cas inhibitors from an initial set of candidate inhibitors. The primary screening assay is followed by secondary screening assay to validate the putative set of inhibitors selected by the preliminary screen. In some embodiments, the present disclosure includes compositions and methods are provided for the inhibition of the function of RNA guided endonucleases, including the identification and use of such inhibitors.


  • 05/09/2019

Published Patent Application

  • WO2019/089761

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