You are here

CRISPR Protein Inhibitors

Application No.

PCT/US2018/058466

Broad Case No.

BI-10277

List of inventors -

Amit Choudhary, Kurt Cox, Elisa Franco, Basudeb Maji, Hari Subramanian, Peng Wu

Abstract

The embodiments disclosed herein utilize fluorescence polarization based preliminary screen to identify a putative set of Cas inhibitors from an initial set of candidate inhibitors. The primary screening assay is followed by secondary screening assay to validate the putative set of inhibitors selected by the preliminary screen. In some embodiments, the present disclosure includes compositions and methods are provided for the inhibition of the function of RNA guided endonucleases, including the identification and use of such inhibitors.

Date PUBLISHED

  • 05/09/2019

Published Patent Application

  • WO2019/089761

PDF Download