CRISPR-Cas systems and methods for altering expression of gene products

Application No.
Broad Case No.

Feng Zhang


The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system.

Date Issued
Published Patent Application
US8697359 B1
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