Compositions, methods and use of synthetic lethal screening

Application No.
PCT/US2015/057567
Broad Case No.
BI-2014/065
Inventors

Myriam Heiman

Abstract

The present invention generally relates to methods of identifying modulators of central nervous system diseases and the use of the moduiators in treatment and diagnosis. The methods utilize a novel high throughput screen that includes injection of a library of barcoded viral vectors expressing shRNA's, CRISPR/Cas systems or cDNA's into animal models of disease and detecting synthetic lethality.

Date Published
Published Patent Application
WO2016/069591
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