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Compositions and methods for treating multiple myeloma

Application No.

PCT/US2016/046856

Broad Case No.

BI-2015/106

List of inventors -

Stuart Schreiber, Shrikanta Chattopadhyay, Zarko Boskovic

Abstract

In one aspect, the present invention provides a method of inhibiting proliferation of a multiple myeloma cell, the method comprising contacting the cell with BRD9647, thereby inhibiting proliferation of the cell. In another aspect, the present invention provides a method of treating multiple myeloma in a pre-selected subject, the method comprising administering an effective amount of BRD9647 to the subject, wherein the subject is pre-selected by detecting a mutation in an AZIN1 polynucleotide or polypeptide relative to a reference in a biological sample obtained from the subject. In another aspect, the present invention provides a method of modulating benzoylation of an agent in a cell, the method comprising contacting the cell with BRD9647, thereby modulating benzoylation of an agent in the cell.

Date PUBLISHED

  • 02/23/2017

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