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Compositions and methods for treating drug-tolerant glioblastoma

Application No.

PCT/US2016/024083

Broad Case No.

BI-2015/164

List of inventors -

Bradley Bernstein, Anoop Patel, Brian Liau, Cem Sievers

Abstract

The present invention provides compositions and methods for the treatment of drug-tolerant glioblastoma, and in particular gliobastoma stem cells. Specifically, the methods comprise contacting a glioblastoma stem cell with a platelet-derived growth factor receptor alpha inhibitor and one or more of a histone lysine demethylase inhibitor and a Notch inhibitor.

Date PUBLISHED

  • 06/15/2017

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