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Compositions and methods for treating cardiac dysfunction

Application No.

PCT/US2016/066390

Broad Case No.

BI-2015/147

List of inventors -

Todd Golub, David Thomas

Abstract

The invention provides compositions and methods for treating cardiac dysfunction, particularly cachexia-associated or RAGE-associated cardiac dysfunction, using an anti-RAGE agent. The invention also provides compositions and methods for identifying therapeutic agents useful for disrupting (slowing, reducing, reversing, or preventing). The methods comprise designing or identifying agents that bind to functional sites identified on the RAGE polypeptide, wherein binding of agents to the functional site(s) inhibit RAGE-mediated cachetogenic signaling.

Date PUBLISHED

  • 06/22/2017

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