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Compositions and methods for targeting cancer-specific sequence variations

Application No.

PCT/US2016/057915

Broad Case No.

BI-2015/120

List of inventors -

William Hahn, David Root, Barbara Weir, Glenn Cowley, Aviad Tsherniak, Andrew Aguirre, April Cook, Francisca Vazquez, Robin Meyers

Abstract

The present invention relates to compositions and methods for targeting cancer-specific DNA sequences, such as copy number amplifications and other types of cancer-specific sequence variations, such as cancer-specific polymorphisms, insertions, or deletions. The present invention provides hereto sequence-specific DNA targeting agents targeting a sequence within the amplified DNA region or a sequence otherwise specific for a cancer cell compared to a non- cancer cell. The invention further relates to methods for treating cancer, comprising administering such sequence-specific DNA targeting agents. The invention further relates to methods for preparing sequence-specific DNA targeting agent, as well as screening methods using the DNA targeting agents.

Date PUBLISHED

  • 05/04/2017

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