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Compositions and methods for evaluating and modulating immune responses by use of immune cell gene signatures

Application No.

PCT/US2016/059507

Broad Case No.

BI-2015/132

List of inventors -

Aviv Regev, Le Cong, Vijay Kuchroo, Meromit Singer, Chao Wang, Ana Anderson

Abstract

The present invention provides markers, marker signatures and molecular targets that correlate with dysfunction of immune cells and are advantageously independent of the immune cell activation status. The present markers, marker signatures and molecular targets provide for new ways to evaluate and modulate immune responses. Therapeutic methods are also provided to treat a patient in need thereof who would benefit from an increased immune response.

Date PUBLISHED

  • 05/04/2017

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