You are here

Cell Atlas of Healthy and Diseased Barrier Tissues

Application No.

PCT/US2018/042557

Broad Case No.

BI-10224

List of inventors -

Jose Ordovas-Montanes, Alexander Shalek

Abstract

Embodiments disclosed herein provide a cell atlas of barrier tissues from healthy and diseased subject. The atlas was obtained by single cell sequencing of approximately 18,036 cells in a surgical data set and 18,704 cells from scrapings. The present invention discloses novel markers for cell types. Moreover, genes associated with disease, including type 2 inflammation are identified. The invention provides for diagnostic assays based on gene markers and cell composition, as well as therapeutic targets for controlling differentiation, proliferation, maintenance and/or function of the cell types disclosed herein. In addition, novel cell types and methods of quantitating, detecting and isolating the cell types are disclosed.

Date PUBLISHED

  • 01/24/2019

Published Patent Application

  • WO2019/018441

PDF Download