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Information about licensing CRISPR genome editing systems

Broad Institute, MIT and Harvard share the goal of developing innovative technologies such as CRISPR genome editing tools and promoting its translation into genomic medicines to benefit patients.

We are committed to making these technologies broadly available for research to help ensure that therapeutic development — bringing this technology to the clinic — has the best chance of success.

  • We make CRISPR tools, knowledge, methods and other IP for genome-editing freely available to the academic and non-profit community. Since 2013, we have freely shared (in collaboration with the non-profit organization Addgene) more than 36,000 CRISPR reagents with academic labs around the world to help accelerate research into virtually every aspect of human health— including cancer, schizophrenia, diabetes, HIV and other infectious diseases.
  • We license CRISPR IP non-exclusively to companies to use in their own commercial research.
  • We also license CRISPR IP non-exclusively to companies wishing to sell tools and reagents for genome editing.
  • For human therapeutics, we concluded that exclusivity is necessary to driving the level of investment needed to develop the technology to the point that it is safe, effective, and capable of precise editing in specific cell types.
  • Broad Institute, Harvard, and MIT therefore developed an approach that we call an “inclusive innovation” model. Under this model, Broad, Harvard, and MIT have licensed their CRISPR technology to a primary licensee, Editas Medicine, Inc. (Editas). Editas has a right to exclusively use the technology on targets of its choosing for the development of genomic medicines. However, after an initial period, other companies may apply to license certain CRISPR IP for use against genes of interest not being pursued by Editas. Specifically:

    (i) a third party interested in an individual gene target would provide a bona fide development plan,
    (ii) Editas then has a pre-defined period to decide whether it intends to pursue the gene of interest and to commit funding and launch a program, and;
    (iii) if Editas is not already working on the gene of interest and chooses not to launch a new program of its own within this period, the IP may be available for licensing by Broad, Harvard, and MIT to the third party.

The goal of our inclusive innovation model is to enable Editas to devote sufficient investment to develop CRISPR-based genome editing technology to treat human diseases, while supporting broad development of medicines to reach many patients.

Parties interested in licensing CRISPR-Cas9 under the inclusive innovation model are invited to contact partnering@broadinstitute.org.

The newly-licensed CRISPR-Cpf1 will later become available under the inclusive innovation model. Please check back here for updates.