Technology Highlights

Many of the Broad's technologies are available to license. Below we have highlighted technologies from the Broad Institute that have recently been featured in scientific publications and press releases. If you are interested in finding out about other technologies not listed below, please contact the Office of Strategic Alliances and Partnering (

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA, Cell, 2014.

Discovery and saturation analysis of cancer genes across 21 tumour types, Nature, 2014.

Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells, Science, 2014.

Genome-scale CRISPR-Cas9 knockout screening in human cells, Science, 2014.
Genetic Screens in Human Cells Using the CRISPR/Cas9 System, Science, 2014.

Identification of small molecules for human hepatocyte expansion and iPS differentiation, Nature Chemical Biology, 2013.

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells, Nature chemical biology, 2013.

An aberrant transcription factor network essential for wnt signaling and stem cell maintenance in glioblastoma, Cell reports, 2013.

Dynamic regulatory network controlling TH17 cell differentiation, Nature, 2013.

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samplesNature Biotechnology, 2013.

Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: IV. viral proteinase slides along DNA to locate and process its substratesJournal of Biological Chemistry, 2013.

Multiplex genome engineering using CRISPR/Cas systems, Science, 2013.

Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains, Nature Communications, 2012.

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion, Nature, 2012.

Absolute quantification of somatic DNA alterations in human cancer Nature Biotechnology, 2012.

RNA signatures allow rapid identification of pathogens and antibiotic susceptibilitiesProceedings of the National Academy of Sciences of the United States of America, 2012.

Comprehensive mapping of long-range interactions reveals folding principles of the human genome, Science, 2009.