Daniel Graham, Ph.D.

Daniel Graham is the director of functional genomics in the Infectious Disease and Microbiome Program at the Broad Institute of MIT and Harvard, where he is also an institute scientist. Graham’s research leverages insights from human genetics to dissect molecular mechanisms of immunity and inflammatory pathologies. His work addresses how genetic and environment factors, such as the microbiome, impact immune function in the context of health and autoimmune disease. The overarching goal of this work is to build towards a deep mechanistic understanding of disease pathology and to guide the development of therapeutic interventions that target underlying causal mechanisms of disease with greater precision, efficacy, and safety. By bridging diverse scientific disciplines through collaboration, these efforts aim to discover fundamental mechanisms of immunity and make direct connections with human biology.
 
Graham’s research collaborations span across the extended Broad community. He is a member of the Center for the Study of Inflammatory Bowel Disease (CSIBD) at Massachusetts General Hospital and Harvard Medical School. He is also a member of the Center for Microbiome Informatics and Therapeutics (CMIT) at MIT. Prior to joining the Broad Institute, Graham completed a postdoctoral fellowship at Washington University School of Medicine in St. Louis in the Division of Immunobiology. He earned a Ph.D. in immunology from the Mayo Clinic College of Medicine and studied biochemistry at Bates College.