News from the Broad

The Broad Institute is committed to open sharing not only of its scientific data and tools, but also information and news about our progress towards achieving our mission. Below are just a few highlights from the Broad scientific community.
  • Study demonstrates central role for NFkB in driving pathophysiology of MS

    June 15th, 2015

    A central regulator of inflammation, nuclear factor kappa B (NFkB), has been implicated as a driver of the autoimmune disease multiple sclerosis (MS). A team led by David Hafler, of the Broad Institute and Yale School of Medicine, demonstrated that MS-associated variants alter NFkB signaling pathways, leading to increased activation of NFkB and making cells more responsive to inflammatory stimuli. The work, featured in Science Translational Medicine, suggests that rapid genetic screening for variants associated with NFκB signaling may identify individuals amenable to therapeutics targeting this pathway.

  • Study examines role of lncRNAs in the brain

    June 10th, 2015

    To investigate the role of long noncoding RNAs (lncRNAs) in brain development, a team led by John Rinn and Paola Arlotta of the Broad Institute and Harvard Stem Cell Institute, and Harvard’s Giulio Tomassy, analyzed the expression of lncRNAs in the developing and adult brain using lncRNA-knockout mouse models. The resulting map of gene expression revealed surprising spatial temporal patterns where a lncRNA is expressed embryonically but not in adult brains and vice-versa. The researchers also found that about 25 percent of lncRNA deletions resulted in a “cis-like” regulatory role on local gene expression. The study, which appears in PNAS, suggests several avenues for future studies on these molecules in brain development and physiology.

  • Global Alliance for Genomics and Health marks two years of progress

    June 10th, 2015
    Over 250 scientific leaders convene in the Netherlands to maximize the potential of genomic medicine
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  • CRISP-Disp leverages CRISPR-Cas9 to deliver RNA structures to targets in the genome

    June 9th, 2015

    A team of researchers from the Broad Institute and the Harvard Stem Cell Institute has developed CRISP-Disp, a method that expands on the CRISPR-Cas9 system, allowing researchers to display multiple, large RNA structures on the Cas9 protein. The method enables the researchers to deliver artificial RNA devices — such as RNA processors, scaffolds, and imaging applications — to specific points on the genome. The work was led by John Rinn who, with his colleagues, is using the approach to better study long, non-coding RNAs (lncRNAs), which are hard to study using traditional knockout methods. With CRISP-Disp, the researchers can relocate lncRNAs to study them in isolation. To learn more, read the team’s paper, which was published online by the journal Nature Methods.

  • Small probes and their bigger implications

    June 8th, 2015

    Human genetics studies provide insight into how an ideal drug might target and modify a disease-causing protein. But, oftentimes, these “experiments of nature” indicate the need for drugs that act through novel mechanisms. A review by Broad Institute researchers Stuart Schreiber, Joanne Kotz, and colleagues published in Cell outlines recently completed, decade-long Molecular Libraries Program (MLP) — an NIH effort to identify small-molecule probes that could help explore human biology. From malaria to multiple sclerosis and diabetes, the authors describe how these probes are enabling the investigation of disease hypotheses that would be difficult to explore via other approaches, advancing therapeutic discovery.