News from the Broad

The Broad Institute is committed to open sharing not only of its scientific data and tools, but also information and news about our progress towards achieving our mission. Below are just a few highlights from the Broad scientific community.
  • Team studies biology of IBD gene CARD9 by examining protective allele

    October 27th, 2015

    The gene CARD9 codes for a central component of the innate anti-fungal immune response and has recently been associated with risk for several immune-related disorders, including inflammatory bowel disease (IBD). New research from the lab of Broad institute member Ramnik Xavier looks to a rare CARD9 variant, which is strongly protective against IBD, to uncover the basic biology of the gene as well as its regulation. The paper, published this week in Immunity, also offers a potential mechanism for the protective allele.

  • Study finds that antibiotics’ effects on cell metabolism contribute to bacterial demise

    October 22nd, 2015

    Historically, most research on newly identified antibiotics has focused on how they work on their direct targets, but new, high-powered technologies have made it possible to examine their effects system-wide. In a study published this week by Cell Reports, a team led by senior author Jim Collins (of the Broad Institute, MIT, and Harvard University's Wyss Institute) and first author Peter Belenky (of Brown University) observed the metabolome of Escherichia coli (E.

  • International team characterizes three potential alternatives to Cas9

    October 22nd, 2015
    New Cas enzymes shed light on evolution of CRISPR-Cas systems; points the way towards rational design of future genome editing tools
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  • Genomic study sheds light on protective effects of malaria vaccine candidate

    October 21st, 2015
    Evidence of allele-specificity helps explain partial protection of RTS,S/AS01
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  • Multi-institutional team successfully performs surgery on a human genome, changing how it is folded inside the cell nucleus

    October 20th, 2015
    A research team spanning Baylor College of Medicine, Rice University, Stanford University, and the Broad Institute of MIT and Harvard has reported the first successful genome surgery, changing how the genome is folded inside the nucleus. The advance may lead to new methods of understanding and overcoming genetic diseases.
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