News from the Broad

The Broad Institute is committed to open sharing not only of its scientific data and tools, but also information and news about our progress towards achieving our mission. Below are just a few highlights from the Broad scientific community.
  • Shining a light on bladder cancer

    May 5th, 2016
    Researchers scrutinize patterns of mutations in bladder tumor genomes, gleaning insights into the roles of DNA repair and tobacco-related DNA damage
    Read Full Story
  • History on ice

    May 3rd, 2016
    Researchers paint a genetic portrait of Ice Age Europe
    Read Full Story
  • What our gut tells us about the ‘hygiene hypothesis’

    April 27th, 2016
    Study of infants from three European countries reveals connection between microbiome, autoimmune disease
    Read Full Story
  • Resisting resistance in tuberculosis

    April 13th, 2016
    Antibiotics do patients no good if the pathogen being targeted is resistant to them. When it comes to tuberculosis, avoiding treatments destined to fail can be lifesaving.
    Read Full Story
  • Hunt for noncoding mutations reveals insights into development of red blood cells

    April 12th, 2016

    Chasing mutations in the coding regions of genes associated with disease is one thing; chasing noncoding or regulatory mutations is another. For a study published last week in the Proceedings of the National Academy of Sciences, a team led by Vijay Sankaran, Aoi Wakabayashi, and Jacob Ulirsch of Boston Children’s Hospital, Dana-Farber Cancer Institute, and Broad Institute used CRISPR genome editing to probe rare mutations — all in noncoding DNA — linked to three red blood cell diseases. Their findings reveal new insights into the intricate dance of transcription factors involved in red blood cell development, and provide a framework for studying the functional changes wrought by mutations in noncoding stretches of the genome.