News from the Broad

The Broad Institute is committed to open sharing not only of its scientific data and tools, but also information and news about our progress towards achieving our mission. Below are just a few highlights from the Broad scientific community.
  • Diverse drivers in lung cancer

    May 18th, 2016

    A team led by Matthew Meyerson (Broad Institute, Dana-Farber Cancer Institute), Ramaswamy Govindan (Washington University School of Medicine), and first author Joshua Campbell (Broad, Dana-Farber) performed exome sequencing on hundreds of samples of two of the most common lung cancer types: lung adenocarcinoma and lung squamous cell carcinoma. Appearing in Nature Genetics, the work revealed that the two share only a handful of mutated genes, so targeted therapies must be tailored for each type. The analysis also found that in both cancer types, around half of tumors had several “neoepitopes” — bits of protein discoverable by the immune system — suggesting that immunotherapy approaches could be successful in many lung tumors. Read more in the ITMO University release and GenomeWeb.

  • Eyeing a new model for studying Duane retraction syndrome

    May 17th, 2016

    Duane retraction syndrome (DRS) is a congenital eye-movement disorder that hinders outward gaze and causes retraction of the eye on attempted inward gaze. A new study from a team led by Elizabeth Engle of Boston Children’s Hospital, Harvard Medical School, and the Broad Institute has identified and analyzed four mutations linked to the syndrome. The findings, published last week in the American Journal of Human Genetics, demonstrate that the disease can be successfully studied in mouse models, and offer new clues to how the disease develops.

  • Study finds that diet and gut microbes may influence inflammation in the brain

    May 16th, 2016

    Working with pre-clinical models for multiple sclerosis (MS) and samples from MS patients, a team led by Broad Institute associate member Francisco Quintana of Brigham and Women’s Hospital and Harvard Medical School found that diet and gut bacteria may influence the activity of astrocytes – star-shaped glial cells in the brain and spinal cord involved in controlling inflammation and neurodegeneration. The work, which was reported in Nature Medicine, suggests potential new therapies for MS. Read more in Harvard Gazette, FierceBiotech, and the Boston Business Journal.

  • Newly identified pathway driving pancreatic cancer shows promise as therapeutic target

    May 12th, 2016
    Pancreatic cancer flourishes sans SIRT6, researchers find
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  • Shining a light on bladder cancer

    May 5th, 2016
    Researchers scrutinize patterns of mutations in bladder tumor genomes, gleaning insights into the roles of DNA repair and tobacco-related DNA damage
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