News from the Broad

The Broad Institute is committed to open sharing not only of its scientific data and tools, but also information and news about our progress towards achieving our mission. Below are just a few highlights from the Broad scientific community.
  • New automated process accelerates generation of induced pluripotent stem cells

    August 11th, 2015

    Reprogramming adult cells to a stem cell-like state can provide researchers with tools to help illuminate the role genetic differences play in disease development and potentially regenerate tissue in the wake of injury. However, these induced pluripotent stem cells (iPSCs) are difficult to create. In a study published this week in Nature Methods, researchers, including Kevin Eggan, Alexander Tsankov, and Alexander Meissner of the Broad Institute and Harvard Stem Cell Institute, describe an automated, robotic process that efficiently generates iPSC lines — a new approach that could facilitate studies with these cells.

  • Out of the lamplight

    July 30th, 2015
    New research from Broad's cell circuits program is the first to apply genome-wide CRISPR screening to primary cells and reveals new and known regulators of an important immune response circuit
    Read Full Story
  • Commentary outlines plan for crowdsourced Chemical Probes Portal

    July 27th, 2015

    Chemical probes — small molecules that interact with a protein’s function — can be powerful tools to reveal the roles of targeted proteins in health and disease, but probes are sometimes of low quality, and high-quality ones can be misused. In a Nature Chemical Biology commentary, a multi-institutional team, including Broad Institute’s Stuart Schreiber, Nathanael Gray, and Joanne Kotz, describe plans for a new community-driven wiki-like site, called the Chemical Probes Portal, that crowdsources medicinal chemistry and pharmacology expertise to catalog the best chemical probes for a given protein target. The resource aims to support research in basic biology and the pursuit of new therapeutics.

  • American History 201

    July 21st, 2015
    Genetic studies link indigenous peoples in the Amazon and Australasia
    Read Full Story
  • Researchers use new methods to localize genetic risk of type 1 diabetes

    July 17th, 2015

    Variation in human leukocyte antigen (HLA) genes accounts for one-half of the genetic risk in type 1 diabetes (T1D), but scientists have found it challenging to pinpoint the specific variants that account for this risk. This week, a team led by Soumya Raychaudhuri and Xinli Hu of Broad Institute and Brigham and Women’s Hospital published a study that used new genotype imputation methods to identify independent amino acid positions, as well as interactions within the HLA region, that account for T1D risk. Taking this approach, they found that three key amino acid positions in HLA-DQ and HLA-DR molecules drive the vast majority of T1D risk. To learn more, read their paper online in Nature Genetics.