News from the Broad

The Broad Institute is committed to open sharing not only of its scientific data and tools, but also information and news about our progress towards achieving our mission. Below are just a few highlights from the Broad scientific community.
  • GA4GH presents vision, model for genomic and clinical data sharing

    June 9th, 2016
    International coalition calls for a new data ecosystem for sharing genomic and clinical data
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  • Direct patient engagement through social media speeds recruitment to cancer research study

    June 4th, 2016
    A crowd-sourcing strategy aimed at accelerating research into metastatic breast cancer has connected advocacy groups, social media, and a dedicated web site to register more than 2,000 patients from all 50 states in its first seven months, say researchers from Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard.
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  • Researchers unlock new CRISPR system for targeting RNA

    June 2nd, 2016
    Discovered in bacteria as viral defense mechanism, researchers program C2c2 to manipulate cellular RNA using CRISPR
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  • New findings on β-cell proliferation points to regenerative medicine approach to diabetes

    May 28th, 2016

    Loss of pancreatic β-cells or their proper function is characteristic of type 1 and type 2 diabetes, so restoring functional β-cell mass has been a major therapeutic goal in the field. A team led by Bridget Wagner at the Broad Institute's Center for the Science of Therapeutics, working with Broad associate member Rohit Kulkarni’s lab at Joslin Diabetes Center, showed that this may be achievable in humans. They found that the kinase-inhibiting enzyme 5-IT, which is known to promote β-cell mass in rodents, can also spark β-cell proliferation in humans by inhibiting the protein DYRK1A. The research, published in Diabetes, suggests a possible regenerative medicine approach to diabetes.

  • First large-scale proteogenomic study of breast cancer provides insight into potential therapeutic targets

    May 25th, 2016
    Building on data from The Cancer Genome Atlas (TCGA) project, a multi-institutional team of scientists has completed the first large-scale “proteogenomic” study of breast cancer, linking DNA mutations to protein signaling and helping pinpoint the genes that drive cancer.
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