Scientists have solved the structure of an important complex of RAS-pathway proteins, explaining how known mutations lead to disease and suggesting potential new binding sites for cancer drugs.
By studying individual cardiac cells from heart failure patients, researchers have identified molecular signatures that point to biological mechanisms of disease.
International collaborations analyze common and rare DNA variants in hundreds of thousands of people, further elucidating genetic roots of psychiatric disorder
Researchers will analyze the DNA of tens of thousands of people from five countries in East and South Asia to find genetic markers for the psychiatric condition.
Broad researchers discover that changes in immune responses and the gut microbial community could underlie repeated occurrences of these common infections.
By introducing cancer-causing mutations into healthy skin cells step-by-step, Broad scientists have created models of skin cancer that can reveal the effects of mutations.
Scientists link dozens of new genome sites to coronary artery disease risk and pioneer a powerful method for illuminating the biological roots of common disease.
A community of computer scientists and physician-scientists at Broad is applying computational approaches to patient data to gain new insights into heart disease.
Nominations are now open for the first award of the Richard N. Merkin Prize in Biomedical Technology, which recognizes novel technologies that have improved human health.