Targeting a unique metabolic pathway might starve pancreatic cancer
Researchers discover that pancreatic ductal adenocarcinoma depends on a unique metabolic pathway to make compounds necessary for its growth
Support for this study was provided by the National Cancer Institute, the National Institute of Allergy and Infectious Diseases, the American Cancer Society, Boston Children’s Hospital, and the Hale Family Center for Pancreatic Cancer Research at Dana-Farber Cancer Institute.
Lee M-S, et al. Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer. Nature. Online March 29, 2023. DOI: 10.1038/s41586-023-05891-2.