Survey of brain cell junctions shows striking similarities between schizophrenia and bipolar disorder
An unbiased protein analysis comparing synapses from people with the disorders uncovers shared patterns.
May 11, 2023

Credit: Sonja Vasiljeva
Protein changes at brain cell synapses from patients with schizophrenia were strikingly similar to those from patients with bipolar disorder.
Funding
Support for this research was provided by the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard.
Paper cited
Aryal S, et al. Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model. Cell Reports. Online May 11, 2023. DOI: 10.1016/j.celrep.2023.112497.