Study reveals how some bacterial infections become chronic
Scientists uncover mutations that allow Salmonella to fly under the immune system’s radar for years
Grote A, Piscon B, Manson AL, et al. Persistent Salmonella infections in humans are associated with mutations in the BarA/SirA regulatory pathway. Cell Host Microbe. 2024;32(1):79-92.e7. doi:10.1016/j.chom.2023.12.001
The work was supported in part by the Israel Science Foundation-Broad Institute Program, the German-Israeli Foundation for Scientific Research and Development, the Research Cooperation Lower Saxony-Israel (The Volkswagen Foundation), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, and the Jane Coffin Childs Memorial Fund for Medical Research postdoctoral fellowship.