Study reveals a driver of brain cell damage in neurodegeneration
Researchers identify a protein in the brain that regulates the complement cascade, which has been linked to Alzheimer’s disease and schizophrenia and is a possible drug target.
Funding:
Support for this research was provided in part by the National Institutes of Health.
Paper cited:
Zhou J, Wade SD, Graykowski D, et al. The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration. Sci. Transl. Med. Online March 29, 2023. DOI: 10.1126/scitranslmed.adf0141.