Search algorithm reveals nearly 200 new kinds of CRISPR systems
By analyzing bacterial data, researchers have discovered thousands of rare new CRISPR systems that have a range of functions and could enable gene editing, diagnostics, and more.
This work was supported by the Howard Hughes Medical Institute; K. Lisa Yang and Hock E. Tan Molecular Therapeutics Center at MIT; Broad Institute Programmable Therapeutics Gift Donors; The Pershing Square Foundation, William Ackman and Neri Oxman; James and Patricia Poitras; BT Charitable Foundation; Asness Family Foundation; Kenneth C. Griffin; the Phillips family; David Cheng; and Robert Metcalfe.
Altae-Tran H, Kannan S, et al. Uncovering the functional diversity of rare CRISPR-Cas systems with deep terascale clustering. Science. Online November 23, 2023. DOI: 10.1126/science.adi1910.