Scientists use genetics to dig into a tumor’s past
A study of tumor exomes reconstructs a timeline of mutations for certain cancer types, revealing insight into the order of genetic drivers of the disease.
The research was supported in part by the National Institute of Dental and Craniofacial Research and the Paul C. Zamecnick, MD, Chair in Oncology at Massachusetts General Hospital.
Leshchiner I, Mroz EA, Cha J, et al. Inferring early genetic progression in cancers with unobtainable premalignant disease. Nature Cancer. Online April 20, 2023. DOI: 10.1038/s43018-023-00533-y.