Researchers map brain cell changes in Alzheimer’s disease
Study reveals key cell structures and gene expression changes near amyloid plaques and tau tangles in mouse brain tissue.
February 2, 2023

Credit: Zeng H, Huang J, Zhou H, et al. Nature Neuroscience. Online February 2, 2023. DOI:10.1038/s41593-022-01251-x.
Fluorescence microscopy image of brain tissue from a mouse model of Alzheimer’s, showing tau tangles (red), amyloid plaques (white), RNA (green), and cell nuclei (blue).
Research support:
This work was supported in part by the Searle Scholars Foundation, the Stanley Center for Psychiatric Research, and the Merkin Institute.
Paper(s) cited:
Zeng H, Huang J, Zhou H, et al. Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer’s disease. Nature Neuroscience. Online February 2, 2023. DOI:10.1038/s41593-022-01251-x.