Researchers map brain cell changes in Alzheimer’s disease
Study reveals key cell structures and gene expression changes near amyloid plaques and tau tangles in mouse brain tissue.
This work was supported in part by the Searle Scholars Foundation, the Stanley Center for Psychiatric Research, and the Merkin Institute.
Zeng H, Huang J, Zhou H, et al. Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer’s disease. Nature Neuroscience. Online February 2, 2023. DOI:10.1038/s41593-022-01251-x.