Researchers identify key source of T cell "exhaustion"
Discovery opens the way to drugs that can prevent T-cell therapies from losing their potency over time.
March 20, 2023

Credit: Alex Ritter, Jennifer Lippincott Schwartz and Gillian Griffiths, National Institutes of Health
Killer T cells (green and red) surround a cancer cell (blue, center).
Funding:
This work was supported in part by the National Institutes of Health, the Switzerland National Science Foundation, the Lymphoma Research Foundation, the National Cancer Institute, the Mark Foundation for Cancer Research Emerging Leader Award, and the Vogelstein Foundation.
Paper cited:
Battistello E, Hixon K, Comstock DE et al. Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion. Molecular Cell. Online March 20, 2023. DOI: 10.1016/j.molcel.2023.02.026