Researchers engineer in vivo delivery system for prime editing, partially restoring vision in mice
By adapting virus-like particles to carry the machinery for a type of gene editing called prime editing, scientists have corrected disease-causing mutations in animals and increased editing efficiency.
Support for the study was provided in part by the National Institutes of Health, the Bill and Melinda Gates Foundation, the Howard Hughes Medical Institute, Foundation Fighting Blindness, the UC Irvine School of Medicine Dean’s office, a Research to Prevent Blindness unrestricted grant, and a National Science Foundation Graduate Research Fellowship.
An, M. et al. Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nature Biotechnology. Online January 8, 2024. DOI: 10.1038/s41587-023-02078-y